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- W35758175 abstract "Publisher Summary The development of human myelomonocytic cell lines has provided useful models for studying regulation of both cell proliferation and differentiation. HL60 is the most widely used of the human myeloid leukemia cell lines for studying differentiation. It was the first human cell line with distinct myeloid features to be developed. The HL60 cell line was isolated from the blood of a patient with what has recently been rediagnosed as acute myeloid leukemia with maturation. HL60 cells are induced by exposure to a wide variety of compounds, including dimethyl sulfoxide (DMSO), hypoxanthine, dimethylformamide (DMF), actinomycin D, and RA. Many of these induced HL60 cells have functional characteristics of normal human peripheral blood granulocytes and monocytes/macrophages including phagocytosis, lysosomal enzyme release, complement receptors, chemotaxis, hexose monophosphate shunt activity, superoxide anion generation, and the ability to reduce nitro blue tetrazolium (NBT). This chapter discusses the retinoic acid induced differentiation and procedures for studying growth and differentiation of HL60 cells." @default.
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- W35758175 date "1990-01-01" @default.
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- W35758175 title "Growth and differentiation of human myeloid leukemia cell line HL60" @default.
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- W35758175 doi "https://doi.org/10.1016/0076-6879(90)90016-t" @default.
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