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• W3579088 abstract "499 Objectives: To determine the utility of FDG-PET scans for initial staging and restaging of T-cell lymphomas. Methods: We retrospectively reviewed 33 FDG-PET scans (7 staging scans and 26 restaging scans) of 16 patients (9 male and 7 female, average age, 44 years) with histologic confirmation of T-cell lymphoma. The lymphomas were classified according to the WHO classification system as: nodal type (7 patients, 18 scans), leukemic type (4 patients, 8 scans), and extranodal/cutaneous type (5 patients, 7 scans). 23 CT scans that were performed within ±4 weeks of the FDG-PET scan were also included for comparison. Clinical parameters, biopsy results, and/or evolution on imaging techniques served as references for the accuracy of PET. Results: 7 FDG-PET scans (6 nodal type and 1 leukemic type) were not included because no clinical or pathology follow-up results were available. Overall, FDG-PET had a sensitivity of 93% and a specificity of 83% for detecting at least one lesion in patients with proven active disease. Corresponding sensitivity and specificity values for CT were 83% and 63%, respectively. All 7 FDG-PET initial staging scans were consistent with malignancy. All but one of them revealed at least one area of FDG uptake concordant with histologic evidence of T-cell lymphoma. Of sub-types of T-cell lymphomas classified according to the WHO system, the nodal group had 100% sensitivity (5/5) and 86% specificity (6/7), the leukemic group had 67% sensitivity (2/3) and 75% specificity (3/4), and the extranodal/cutaneous group had 100% sensitivity (6/6) and 100% specificity (1/1). FDG-PET scans also revealed a greater number of lesions than CT scans taken within 4 weeks in 67% of the time. Conclusions: The initial findings suggest that FDG-PET imaging has higher diagnostic accuracy and demonstrates more areas of involvement than CT in detecting T-cell lymphoma lesions. FDG-PET imaging has clinical utility in both initial staging and restaging of T-cell lymphoma by accurately displaying malignant lesions that may not be clinically apparent or meet the size criteria of malignancy on CT. In our limited number of patients, FDG-PET appears to have a higher diagnostic value in detecting nodal and extranodal/cutaneous types than the leukemic type T-cell lymphoma." @default.
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• W3579088 date "2007-05-01" @default.
• W3579088 modified "2023-09-27" @default.
• W3579088 title "18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in evaluation of T-cell non-Hodgkin's lymphoma" @default.
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