Matches in SemOpenAlex for { <https://semopenalex.org/work/W358003085> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W358003085 abstract "The susceptibility to severe Streptococcus pneumoniae is associated with a variety of human primary immunodeficiencies. Previous studies in human inherited defects showed several immune responses that were critical for this protection: antibody- and complement-mediated opsonization, the spleen and NF-KB-mediated immune responses. Recently, human Interleukin-l-receptor-associated-kinase-4 (IRAK-4) deficiency which presented a complete impairment in most Toll-like receptors' (TLRs) signaling was found and patients suffered from mostly pyogenic bacterial infections, especially caused by S. Pneumoniae. To provide a global view, we diagnosed up to 28 patients with IRAK-4 deficiency and assessed blood TLRs responses and the production of multiple cytokines in individual leukocyte subsets, which revealed a multi-cytokines and —leukocytes impairment upon TLRs activation. Most patients (22/28, 79%) suffered from invasive pneumococcal disease, often recurrent (13/22, 59%). Other infections were rare, with the exception of severe staphylococcal disease. Almost half the patients died (12/28, 43%). No death or invasive infection occurred in patients over 8 and 14 years of age, respectively. The TIR-1RAK-4 pathway is therefore vital for childhood immunity to pyogenic bacteria and plays a non-redundant role in the immunity against S. Pneumoniae. LRAK-4-dependent human TLRs appear to be less important in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria." @default.
- W358003085 created "2016-06-24" @default.
- W358003085 creator A5090139873 @default.
- W358003085 date "2007-01-01" @default.
- W358003085 modified "2023-09-27" @default.
- W358003085 title "Human IRAK-4 deficiency and invasive pneumococcal disease" @default.
- W358003085 hasPublicationYear "2007" @default.
- W358003085 type Work @default.
- W358003085 sameAs 358003085 @default.
- W358003085 citedByCount "0" @default.
- W358003085 crossrefType "dissertation" @default.
- W358003085 hasAuthorship W358003085A5090139873 @default.
- W358003085 hasConcept C126322002 @default.
- W358003085 hasConcept C136449434 @default.
- W358003085 hasConcept C159654299 @default.
- W358003085 hasConcept C168507396 @default.
- W358003085 hasConcept C203014093 @default.
- W358003085 hasConcept C2779134260 @default.
- W358003085 hasConcept C2779341262 @default.
- W358003085 hasConcept C2781253189 @default.
- W358003085 hasConcept C501593827 @default.
- W358003085 hasConcept C71924100 @default.
- W358003085 hasConcept C86803240 @default.
- W358003085 hasConcept C8891405 @default.
- W358003085 hasConcept C89372155 @default.
- W358003085 hasConcept C89423630 @default.
- W358003085 hasConceptScore W358003085C126322002 @default.
- W358003085 hasConceptScore W358003085C136449434 @default.
- W358003085 hasConceptScore W358003085C159654299 @default.
- W358003085 hasConceptScore W358003085C168507396 @default.
- W358003085 hasConceptScore W358003085C203014093 @default.
- W358003085 hasConceptScore W358003085C2779134260 @default.
- W358003085 hasConceptScore W358003085C2779341262 @default.
- W358003085 hasConceptScore W358003085C2781253189 @default.
- W358003085 hasConceptScore W358003085C501593827 @default.
- W358003085 hasConceptScore W358003085C71924100 @default.
- W358003085 hasConceptScore W358003085C86803240 @default.
- W358003085 hasConceptScore W358003085C8891405 @default.
- W358003085 hasConceptScore W358003085C89372155 @default.
- W358003085 hasConceptScore W358003085C89423630 @default.
- W358003085 hasLocation W3580030851 @default.
- W358003085 hasOpenAccess W358003085 @default.
- W358003085 hasPrimaryLocation W3580030851 @default.
- W358003085 hasRelatedWork W2013038545 @default.
- W358003085 hasRelatedWork W2024544474 @default.
- W358003085 hasRelatedWork W2039933503 @default.
- W358003085 hasRelatedWork W2046175615 @default.
- W358003085 hasRelatedWork W2062449054 @default.
- W358003085 hasRelatedWork W2095754831 @default.
- W358003085 hasRelatedWork W2109830199 @default.
- W358003085 hasRelatedWork W2120233207 @default.
- W358003085 hasRelatedWork W2121891913 @default.
- W358003085 hasRelatedWork W2141040025 @default.
- W358003085 hasRelatedWork W2151758954 @default.
- W358003085 hasRelatedWork W2164547339 @default.
- W358003085 hasRelatedWork W2165961510 @default.
- W358003085 hasRelatedWork W2810895786 @default.
- W358003085 hasRelatedWork W2907031173 @default.
- W358003085 hasRelatedWork W2912184946 @default.
- W358003085 hasRelatedWork W2957402062 @default.
- W358003085 hasRelatedWork W2983328933 @default.
- W358003085 hasRelatedWork W3036201966 @default.
- W358003085 hasRelatedWork W761785944 @default.
- W358003085 isParatext "false" @default.
- W358003085 isRetracted "false" @default.
- W358003085 magId "358003085" @default.
- W358003085 workType "dissertation" @default.