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• W35889576 abstract "The pharmacokinetic (PK) and/or pharmacodynamic (PD) profile of drugs in obese individuals may be altered due to associated (patho)physiological changes, necessitating adapted dosing algorithms. Until recently, the obese population was hardly studied in pharmacometric analyses. The influence of obesity on PK and PD parameters has received more attention, given the strong rise in obesity incidence and prevalence across the world. In this review, an overview is given of obesity-related body size descriptors and reported equations quantifying obesity-related changes in population, PK and PD parameters, including how these equations were validated. This chapter shows that many different size descriptors and other covariates in many different equations (linear or nonlinear) have been identified as predictors for the PK parameter clearance and volume of distribution, resulting in complex equations. For clearance, a decrease, increase or unchanged value was reported depending on the elimination pathway and studied population. Volume of distribution was found to increase or remained unchanged, although limited data were available to identify the influence of obesity on this parameter. Very few studies have been performed on the PD profile of drugs in obese patients. It can be concluded that more PK and PD studies in obesity are needed and that future models should be properly evaluated and validated. This chapter will raise important issues for the design of future studies and also the evaluation criteria for covariate modelling to avoid model misspecification." @default.
• W35889576 created "2016-06-24" @default.
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• W35889576 date "2014-01-01" @default.
• W35889576 modified "2023-10-04" @default.
• W35889576 title "Applied Pharmacometrics in the Obese Population" @default.
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• W35889576 doi "https://doi.org/10.1007/978-1-4939-1304-6_6" @default.
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