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- W358973013 abstract "This chapter discusses a study focusing on coupling of electrochemical and enzymatic reactions for controlled drug release. Copolymers of 4-vinylpyridine (4-VP) and vinylferrocene (VF) quaternized with 1-chloroethanol or iodomethane were synthesized and the enzyme, glucose oxidase (GOx) incorporated by covalent bonding to the pyridine. The copolymers were synthesized in a 1:7 and 1:1 mole ratio of VF/4-VP, respectively. Spectrophotometric assay of enzyme activity demonstrated that the enzyme was active after its immobilization in the copolymers. Carbon paste electrodes were prepared by mixing the paste with the copolymers. They were tested for the electroregeneration of the enzyme cofactor when dipped in a glucose solution 0.5549 M, at pH 5.1 in acetate buffer or at pH 7.1 in phosphate buffer solution. The studies were conducted using cyclic voltammetry and amperometry. Small catalytic current was observed as a result of the enzymatic reaction. Pellets of 4-VP and VF copolymer quaternized with 1-chloroethanol with the immobilized GOx and insulin incorporated by physical entrapment were made. The release of insulin was monitored measuring its absorbance in 278 nm as function of time. Insulin release was observed with an approximate t R (95%) = 9.18 min." @default.
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- W358973013 date "1994-01-01" @default.
- W358973013 modified "2023-10-02" @default.
- W358973013 title "Coupling Electrochemical and Enzymatic Reactions for Controlled Drug Release" @default.
- W358973013 doi "https://doi.org/10.1016/b978-1-85617-242-4.50282-2" @default.
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