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- W35996663 abstract "ABSTRACT IgA and IgM autoantibodies against the β-chain of ATP synthase (ASA) have been separately described in different cohort of patients with coeliac disease and nephrotic syndrome. In the later case, they occur in concomitance with anti-actin IgM and/or with anti-nuclear autoantibodies that indicate some parallelism with systemic lupus erythematosus (SLE). ASA IgM were found in children who developed nephrotic syndrome under 15 years and presented resistance or dependence to steroids and cyclosporine. Focal segmental glomerulosclerosis and mesangial proliferation with IgM deposition was the histology background in almost all cases. Patients positive for circulating ASA IgM could not be separated from other nephrotic patients on clinical grounds and represent a subset with uncertain significance. Further screening studies will better define clinical implications and inconsistencies and possibly define personalized therapeutic approaches." @default.
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- W35996663 date "2007-01-01" @default.
- W35996663 modified "2023-10-17" @default.
- W35996663 title "ANTI-ATP SYNTHASE β-CHAIN AUTOANTIBODIES" @default.
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- W35996663 doi "https://doi.org/10.1016/b978-044452763-9/50071-8" @default.
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