Matches in SemOpenAlex for { <https://semopenalex.org/work/W36000590> ?p ?o ?g. }
- W36000590 endingPage "774" @default.
- W36000590 startingPage "765" @default.
- W36000590 abstract "Inflammation of the arterial wall in giant cell arteritis induces a series of structural changes, including the formation of new vasa vasorum. To study the regulation of neoangiogenesis in giant cell arteritis, temporal arteries were examined for the extent and localization of microvessel generation and for the production of angiogenic factors. In normal arteries, vasa vasorum were restricted to the adventitia, but in inflamed arteries, capillaries emerged in the media and the intima. These capillaries displayed a distinct topography with a circumferential arrangement in the external one-third of the intima. Neovascularization was closely correlated with the formation of lumen-obstructing intima, the fragmentation of the internal elastic lamina, and the presence of multinucleated giant cells. Comparison of tissue cytokine transcription in temporal arteries of giant cell arteritis patients with and without up-regulated neoangiogenesis identified interferon-gamma and vascular endothelial growth factor but not fibroblast growth factor-2 as mediators associated with vasa vasorum proliferation. Giant cells and CD68-positive macrophages at the media-intima junction were found to be the major cellular sources of vascular endothelial growth factor. These data demonstrate that formation of new vasa vasorum in vasculitis is regulated by inflammatory cells and not by arterial wall cells, raising the possibility that it represents a primary disease mechanism and not a secondary hypoxia-induced event. Increased neovascularization in interferon-gamma-rich arteries suggests that the formation of new vasa vasorum is determined by the nature of the immune response in the arterial wall, possibly resulting from the generation and functional activity of multinucleated giant cells." @default.
- W36000590 created "2016-06-24" @default.
- W36000590 creator A5016250824 @default.
- W36000590 creator A5024191146 @default.
- W36000590 creator A5056331197 @default.
- W36000590 creator A5056587089 @default.
- W36000590 creator A5086435078 @default.
- W36000590 date "1999-09-01" @default.
- W36000590 modified "2023-09-29" @default.
- W36000590 title "Formation of New Vasa Vasorum in Vasculitis" @default.
- W36000590 cites W116317464 @default.
- W36000590 cites W1581419382 @default.
- W36000590 cites W1581966885 @default.
- W36000590 cites W1679229092 @default.
- W36000590 cites W1817465123 @default.
- W36000590 cites W1854803455 @default.
- W36000590 cites W1975835182 @default.
- W36000590 cites W1985712533 @default.
- W36000590 cites W1987316799 @default.
- W36000590 cites W1989157277 @default.
- W36000590 cites W1989903801 @default.
- W36000590 cites W1994360534 @default.
- W36000590 cites W2000000541 @default.
- W36000590 cites W2004275751 @default.
- W36000590 cites W2010888269 @default.
- W36000590 cites W2015058903 @default.
- W36000590 cites W2022027604 @default.
- W36000590 cites W2022063420 @default.
- W36000590 cites W2023615599 @default.
- W36000590 cites W2057576736 @default.
- W36000590 cites W2074010047 @default.
- W36000590 cites W2079864380 @default.
- W36000590 cites W2084843666 @default.
- W36000590 cites W2088301689 @default.
- W36000590 cites W2090492904 @default.
- W36000590 cites W2091058122 @default.
- W36000590 cites W2100724662 @default.
- W36000590 cites W2104022104 @default.
- W36000590 cites W2115927824 @default.
- W36000590 cites W2120582139 @default.
- W36000590 cites W2158965678 @default.
- W36000590 cites W2299322376 @default.
- W36000590 cites W2399119782 @default.
- W36000590 cites W2411042482 @default.
- W36000590 cites W2418375317 @default.
- W36000590 cites W54905749 @default.
- W36000590 cites W2067688851 @default.
- W36000590 doi "https://doi.org/10.1016/s0002-9440(10)65175-9" @default.
- W36000590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866901" @default.
- W36000590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10487834" @default.
- W36000590 hasPublicationYear "1999" @default.
- W36000590 type Work @default.
- W36000590 sameAs 36000590 @default.
- W36000590 citedByCount "209" @default.
- W36000590 countsByYear W360005902012 @default.
- W36000590 countsByYear W360005902013 @default.
- W36000590 countsByYear W360005902014 @default.
- W36000590 countsByYear W360005902015 @default.
- W36000590 countsByYear W360005902016 @default.
- W36000590 countsByYear W360005902017 @default.
- W36000590 countsByYear W360005902018 @default.
- W36000590 countsByYear W360005902019 @default.
- W36000590 countsByYear W360005902020 @default.
- W36000590 countsByYear W360005902021 @default.
- W36000590 countsByYear W360005902022 @default.
- W36000590 countsByYear W360005902023 @default.
- W36000590 crossrefType "journal-article" @default.
- W36000590 hasAuthorship W36000590A5016250824 @default.
- W36000590 hasAuthorship W36000590A5024191146 @default.
- W36000590 hasAuthorship W36000590A5056331197 @default.
- W36000590 hasAuthorship W36000590A5056587089 @default.
- W36000590 hasAuthorship W36000590A5086435078 @default.
- W36000590 hasBestOaLocation W360005902 @default.
- W36000590 hasConcept C105702510 @default.
- W36000590 hasConcept C134018914 @default.
- W36000590 hasConcept C142724271 @default.
- W36000590 hasConcept C2776015282 @default.
- W36000590 hasConcept C2776205367 @default.
- W36000590 hasConcept C2776712624 @default.
- W36000590 hasConcept C2776716733 @default.
- W36000590 hasConcept C2779134260 @default.
- W36000590 hasConcept C2779205420 @default.
- W36000590 hasConcept C2992686903 @default.
- W36000590 hasConcept C71924100 @default.
- W36000590 hasConcept C77076574 @default.
- W36000590 hasConcept C86803240 @default.
- W36000590 hasConcept C95444343 @default.
- W36000590 hasConceptScore W36000590C105702510 @default.
- W36000590 hasConceptScore W36000590C134018914 @default.
- W36000590 hasConceptScore W36000590C142724271 @default.
- W36000590 hasConceptScore W36000590C2776015282 @default.
- W36000590 hasConceptScore W36000590C2776205367 @default.
- W36000590 hasConceptScore W36000590C2776712624 @default.
- W36000590 hasConceptScore W36000590C2776716733 @default.
- W36000590 hasConceptScore W36000590C2779134260 @default.
- W36000590 hasConceptScore W36000590C2779205420 @default.
- W36000590 hasConceptScore W36000590C2992686903 @default.
- W36000590 hasConceptScore W36000590C71924100 @default.