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- W36013354 abstract "Abstract : We evaluated a large dose of human butyrylcholinesterase (Hu-BChE) in rhesus monkeys using a complex cognitive test (serial-probe recognition, SPR) designed to assess attention and short-term memory. Concurrent with the cognitive-behavioral assessment, blood was collected at critical points throughout the study and was analyzed for AChE and BChE activity, anti-BChE (antibody) activity, and gross clinical pathology (i.e., complete blood count and CHEM 20 panel). Each monkey received an injection of 150 mg (105,000 U or 32 mg/kg) of Hu-BChE 60 min prior to testing on the SPR task. No cognitive-behavioral decrements of any kind were detected in SPR performance and no robust or consistent signs of clinical pathology were detected in any of the blood assays during the 5 weeks of observation. The pharmacokinetics of intravenous Hu-BChE administration revealed a peak in BChE of 226 U/ml at 5 minutes post injection and a mean residence time of approximately 72 hours. These results provide strong support for the behavioral and physiological safety of Hu-BChE in rhesus monkeys." @default.
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- W36013354 date "2005-10-01" @default.
- W36013354 modified "2023-09-26" @default.
- W36013354 title "Evaluating the Behavioral and Physiological Safety of Human Butyrylcholinesterase in Rhesus Monkeys" @default.
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