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- W360511892 abstract "Epidemiological studies suggest that maternal undernutrition, obesity, and diabetes during gestation and lactation can all produce obesity in offspring. Animal models provide a means of assessing the independent consequences of altering the preversus postnatal environments on a variety of metabolic, physiologic, and neuroendocrine functions that lead to the development of offspring obesity, diabetes, hypertension, and hyperlipidemia. During the gestational period, maternal malnutrition, obesity, type 1 and type 2 diabetes, and psychological, immunological, and pharmacological Stressors can all promote offspring obesity. Normal postnatal nutrition can sometimes reduce the adverse impact of some of these prenatal factors but may also exacerbate the development of obesity and diabetes in offspring of dams that were malnourished during gestation. The genetic background of the individual is also an important determinant of outcome when the perinatal environment is perturbed. Individuals with an obesity-prone genotype are more likely to be adversely affected by factors such as maternal obesity and high-fat diets. Many perinatal manipulations are associated with reorganization of the central neural pathways that regulate food intake, energy expenditure, and storage in ways that enhance the development of obesity and diabetes in offspring. Both leptin and insuli n have strong neurotrophi c properties so that either an excess or an absence of either during the perinatal period may underlie some of these adverse developmental changes. Because perinatal manipulations can permanently and adversely alter the systems that regulate energy homeostasis, it behooves us to gain a better understanding of the factors during this period that promote the development of offspring obesity as a means of stemming the tide of the emerging worldwide obesity epidemic." @default.
- W360511892 created "2016-06-24" @default.
- W360511892 creator A5091040652 @default.
- W360511892 date "2007-10-17" @default.
- W360511892 modified "2023-09-27" @default.
- W360511892 title "Critical Importance of the Perinatal Period in the Development of Obesity" @default.
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