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- W36078999 abstract "ABSTRACT Hyaluronan (HA) is the characteristic polysaccharide component of vitreous humor (from which it was first purified 1 ), Wharton's jelly and synovial fluid. The unusual mechanical properties of these gels and viscoeleastic fluids were attributed non-specifically to interactions between HA molecules, which are stiff in solution partly because they prefer to take up 2-fold helical secondary structures, stabilised by H-bonds 2 (Fig 1A). HA has since been found in many tissues from many species 3 . Probably all animals produce it. Unexpectedly, a new class of specific and potent biological activities shown by HA fragments (in angiogenesis, inflammation etc) emerged 4–6 . Highly polymerised HA does not share these properties. HA is vitally important during development 7 . It is a pluripotent material with a simple strucure (Fig 1A). Is there a unifying concept behind this diversity? We suggest that physiological properties of HA are controlled and sequestered by reversible tertiary structures 8 . We introduce an NMR approach which can monitor their formation and behaviour. Biological properties may thereby be linked to specific chemical aspects of HA and HA supramolecular organisation." @default.
- W36078999 created "2016-06-24" @default.
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- W36078999 date "2002-01-01" @default.
- W36078999 modified "2023-09-23" @default.
- W36078999 title "BIOLOGICAL PROPERTIES OF HYALURONAN ARE CONTROLLED AND SEQUESTERED BY TERTIARY STRUCTURES" @default.
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- W36078999 doi "https://doi.org/10.1533/9781845693121.123" @default.
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