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- W361444327 abstract "OBJECTIVE: To examine the association between self-reported sleep problems and incidence of dementia in community-dwelling elderly people. BACKGROUND: Identifying early risk factors on indicators that may better inform our understanding of neurodegenerative disorders, is of paramount importance to current research. Given the mounting evidence that has linked sleep related disorders to both cognitive decline and pathological processes of dementia, sleep problems are as a significant topic of interest within this field. DESIGN/METHODS: We conducted a longitudinal study in a sample of 1041 participants, over 65 years old, recruited from the community, part of the Washington Heights Inwood Community Aging Project (WHICAP). Sleep problems were estimated using the RAND Medical Outcome Study Sleep Scale examining: sleep disturbance, snoring, sleep short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and risk for dementia with the main outcome measure be incident dementia. Age, gender, education, ethnicity, ApoE4, stroke, heart disease, hypertension, diabetes, and depression were used as covariates. RESULTS: In a 3 years follow-up, incidence of dementia was associated with increased daytime sleepiness (B=.222, p=.035) at baseline, after adjusting for age, gender, education, ethnicity, ApoE4, and depression. The result remained significant, after further adjusting for stroke, heart disease, hypertension, and diabetes (B=.219, p=.047). CONCLUSIONS: Our results suggest that increased daytime sleepiness is independent risk factor for dementia in older adults. Study Supported by: WHICAP grant numer:R01AG037212, Felloship in memory of 9Maria Zaousi9 Disclosure: Dr. Tsapanou has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Scarmeas has received personal compensation for activities with Novartis. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant." @default.
- W361444327 created "2016-06-24" @default.
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- W361444327 date "2015-04-06" @default.
- W361444327 modified "2023-10-03" @default.
- W361444327 title "Self-reported sleep problems and incidence of dementia (P2.173)" @default.
- W361444327 hasPublicationYear "2015" @default.
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