Matches in SemOpenAlex for { <https://semopenalex.org/work/W361930701> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W361930701 endingPage "89" @default.
- W361930701 startingPage "89" @default.
- W361930701 abstract "Pyrazinamide is use for the treatment of tuberculosis in all over the world. Bio kinetics deals with the mathematical description of drug changes in the body with time function. This study was designed to investigate the bio kinetics of Pyrazinamide after oral administration of Pyrazinamide (25mg) tablet in 10 healthy volunteers. The blood samples of each volunteer were collected from 0.5 to 12 hours at different time intervals after the medication. The concentration of Pyrazinamide in plasma samples were determined by high performance liquid chromatography (HPLC). Quantitative observations were recorded that include the mean ± SD value of absorption rate constant (Ka), time to peak (Tmax) and peak concentration (Cmax) were 0.38 ± 0.25/h, 2.248 ± 0.64 h and 4.165 ± 2.13µg/mL, respectively. The mean ± SD values of absorption half-life (t1/2a) and elimination half-life (t1/2b) were 2.078 ± 1.678h and 0.2908 ± 1.721 hours. The mean ± SD values of volume of distribution and total body clearance were 40 ± 27.4L and 3.351 ± 1.27 h, respectively. Mean residue time (MRT) showed mean ± SD and area under curve (AUC) were 17.23 ± 12.78 h and 90.4 ± 76.2 h.mg/L, respectively." @default.
- W361930701 created "2016-06-24" @default.
- W361930701 creator A5089239462 @default.
- W361930701 date "2015-01-01" @default.
- W361930701 modified "2023-09-26" @default.
- W361930701 title "HPLC Analysis and Bio-kinetics Study of Pyrazinamide in Healthy Volunteers After Oral Administration" @default.
- W361930701 cites W1926932272 @default.
- W361930701 cites W2002868936 @default.
- W361930701 cites W2006392678 @default.
- W361930701 cites W2016173021 @default.
- W361930701 cites W2044991893 @default.
- W361930701 cites W2077900235 @default.
- W361930701 cites W2087076435 @default.
- W361930701 cites W2095544141 @default.
- W361930701 cites W2098335911 @default.
- W361930701 cites W2099857370 @default.
- W361930701 cites W2119960901 @default.
- W361930701 cites W2132366484 @default.
- W361930701 cites W2132533539 @default.
- W361930701 cites W2139724863 @default.
- W361930701 cites W2157660334 @default.
- W361930701 cites W2170813681 @default.
- W361930701 cites W2408979770 @default.
- W361930701 cites W2440832489 @default.
- W361930701 doi "https://doi.org/10.11648/j.sr.20150303.17" @default.
- W361930701 hasPublicationYear "2015" @default.
- W361930701 type Work @default.
- W361930701 sameAs 361930701 @default.
- W361930701 citedByCount "0" @default.
- W361930701 crossrefType "journal-article" @default.
- W361930701 hasAuthorship W361930701A5089239462 @default.
- W361930701 hasBestOaLocation W3619307011 @default.
- W361930701 hasConcept C112705442 @default.
- W361930701 hasConcept C125287762 @default.
- W361930701 hasConcept C139254425 @default.
- W361930701 hasConcept C159985019 @default.
- W361930701 hasConcept C179998833 @default.
- W361930701 hasConcept C185592680 @default.
- W361930701 hasConcept C192562407 @default.
- W361930701 hasConcept C192670549 @default.
- W361930701 hasConcept C22979827 @default.
- W361930701 hasConcept C2776768635 @default.
- W361930701 hasConcept C2777056448 @default.
- W361930701 hasConcept C2778607973 @default.
- W361930701 hasConcept C2780459521 @default.
- W361930701 hasConcept C3941253 @default.
- W361930701 hasConcept C43617362 @default.
- W361930701 hasConcept C501593827 @default.
- W361930701 hasConcept C55493867 @default.
- W361930701 hasConcept C6557445 @default.
- W361930701 hasConcept C71924100 @default.
- W361930701 hasConcept C86803240 @default.
- W361930701 hasConcept C98274493 @default.
- W361930701 hasConceptScore W361930701C112705442 @default.
- W361930701 hasConceptScore W361930701C125287762 @default.
- W361930701 hasConceptScore W361930701C139254425 @default.
- W361930701 hasConceptScore W361930701C159985019 @default.
- W361930701 hasConceptScore W361930701C179998833 @default.
- W361930701 hasConceptScore W361930701C185592680 @default.
- W361930701 hasConceptScore W361930701C192562407 @default.
- W361930701 hasConceptScore W361930701C192670549 @default.
- W361930701 hasConceptScore W361930701C22979827 @default.
- W361930701 hasConceptScore W361930701C2776768635 @default.
- W361930701 hasConceptScore W361930701C2777056448 @default.
- W361930701 hasConceptScore W361930701C2778607973 @default.
- W361930701 hasConceptScore W361930701C2780459521 @default.
- W361930701 hasConceptScore W361930701C3941253 @default.
- W361930701 hasConceptScore W361930701C43617362 @default.
- W361930701 hasConceptScore W361930701C501593827 @default.
- W361930701 hasConceptScore W361930701C55493867 @default.
- W361930701 hasConceptScore W361930701C6557445 @default.
- W361930701 hasConceptScore W361930701C71924100 @default.
- W361930701 hasConceptScore W361930701C86803240 @default.
- W361930701 hasConceptScore W361930701C98274493 @default.
- W361930701 hasIssue "3" @default.
- W361930701 hasLocation W3619307011 @default.
- W361930701 hasOpenAccess W361930701 @default.
- W361930701 hasPrimaryLocation W3619307011 @default.
- W361930701 hasRelatedWork W2034627982 @default.
- W361930701 hasRelatedWork W2067196841 @default.
- W361930701 hasRelatedWork W2089457465 @default.
- W361930701 hasRelatedWork W2093306462 @default.
- W361930701 hasRelatedWork W2372468048 @default.
- W361930701 hasRelatedWork W2403715195 @default.
- W361930701 hasRelatedWork W2408276775 @default.
- W361930701 hasRelatedWork W2743096795 @default.
- W361930701 hasRelatedWork W361930701 @default.
- W361930701 hasRelatedWork W2120411052 @default.
- W361930701 hasVolume "3" @default.
- W361930701 isParatext "false" @default.
- W361930701 isRetracted "false" @default.
- W361930701 magId "361930701" @default.
- W361930701 workType "article" @default.