FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W36218318> ?p ?o ?g. }

• W36218318 endingPage "2104" @default.
• W36218318 startingPage "2104" @default.
• W36218318 abstract "2104 Objectives To evaluate that compartment model corrected blood input function (MCBIF) estimation (1), from small animal PET images in mice, in-vivo, improves with OSEM-MAP and cardiac gating (2) as compared to un-gated FBP reconstructed images. Methods Imaging of mice (n=3) was initiated under isoflurane anesthesia with the microPET scanner right after FDG administration to capture the initial time points. All the images acquired for an hour were reconstructed using OSEM-MAP into 23 time bins and 3 cardiac bins and into 23 time bins with no gates using FBP reconstruction algorithm. Blood samples were also obtained for each of the mice at late time points where the spill-over (SP) of radioactivity from the myocardium to the blood pool is expected to be high. Time activity curves were generated by drawing regions of interest in the blood-pool (BP) and the myocardial wall. Optimization of MCBIF was performed in MATLAB by simultaneous estimation of the compartment model parameters and the blood input function with SP and partial volume (PV) corrections using extended least squares (ELS). Results Figure 1A shows transverse PET images obtained from OSEM-MAP gated and FBP un-gated reconstructed images at the last time bin. Corresponding MCBIF estimates (figure 1B) are shown along with blood samples at 43 and 56 minutes post FDG administration. The resulting net myocardial FDG influx constant, Ki, was also computed. Conclusions Lower SP of radioactivity from the myocardium to the BP and higher recovery of BP radioactivity (PV) from OSEM-MAP gated images (figure 1A) lead to improved MCBIF estimate (solid curve with triangles) as compared to that obtained from un-gated FBP images (solid curve with squares), especially at the late time point. Mean myocardial Ki (0.196±0.013) computed using the rate constants generated by optimization of blood input function from OSEM-MAP gated images agreed well with that obtained using arterial blood sampling (0.14±0.07)(1), as the difference did not reach statistical significance on a Student t-test (p=0.24) Research Support NIH R21HL10262" @default.
• W36218318 created "2016-06-24" @default.
• W36218318 creator A5035655436 @default.
• W36218318 creator A5045706753 @default.
• W36218318 creator A5089280467 @default.
• W36218318 date "2011-05-01" @default.
• W36218318 modified "2023-09-23" @default.
• W36218318 title "Compartment model corrected blood input function estimation improves with iterative image reconstruction and cardiac gating" @default.
• W36218318 hasPublicationYear "2011" @default.
• W36218318 type Work @default.
• W36218318 sameAs 36218318 @default.
• W36218318 citedByCount "1" @default.
• W36218318 countsByYear W362183182012 @default.
• W36218318 crossrefType "journal-article" @default.
• W36218318 hasAuthorship W36218318A5035655436 @default.
• W36218318 hasAuthorship W36218318A5045706753 @default.
• W36218318 hasAuthorship W36218318A5089280467 @default.
• W36218318 hasConcept C105702510 @default.
• W36218318 hasConcept C111368507 @default.
• W36218318 hasConcept C111566952 @default.
• W36218318 hasConcept C121332964 @default.
• W36218318 hasConcept C126838900 @default.
• W36218318 hasConcept C127313418 @default.
• W36218318 hasConcept C136229726 @default.
• W36218318 hasConcept C141379421 @default.
• W36218318 hasConcept C154945302 @default.
• W36218318 hasConcept C164705383 @default.
• W36218318 hasConcept C178910020 @default.
• W36218318 hasConcept C194544171 @default.
• W36218318 hasConcept C203635412 @default.
• W36218318 hasConcept C2776127602 @default.
• W36218318 hasConcept C2776359302 @default.
• W36218318 hasConcept C2778198053 @default.
• W36218318 hasConcept C2989005 @default.
• W36218318 hasConcept C31972630 @default.
• W36218318 hasConcept C37557685 @default.
• W36218318 hasConcept C41008148 @default.
• W36218318 hasConcept C42219234 @default.
• W36218318 hasConcept C42407357 @default.
• W36218318 hasConcept C71924100 @default.
• W36218318 hasConcept C82233179 @default.
• W36218318 hasConceptScore W36218318C105702510 @default.
• W36218318 hasConceptScore W36218318C111368507 @default.
• W36218318 hasConceptScore W36218318C111566952 @default.
• W36218318 hasConceptScore W36218318C121332964 @default.
• W36218318 hasConceptScore W36218318C126838900 @default.
• W36218318 hasConceptScore W36218318C127313418 @default.
• W36218318 hasConceptScore W36218318C136229726 @default.
• W36218318 hasConceptScore W36218318C141379421 @default.
• W36218318 hasConceptScore W36218318C154945302 @default.
• W36218318 hasConceptScore W36218318C164705383 @default.
• W36218318 hasConceptScore W36218318C178910020 @default.
• W36218318 hasConceptScore W36218318C194544171 @default.
• W36218318 hasConceptScore W36218318C203635412 @default.
• W36218318 hasConceptScore W36218318C2776127602 @default.
• W36218318 hasConceptScore W36218318C2776359302 @default.
• W36218318 hasConceptScore W36218318C2778198053 @default.
• W36218318 hasConceptScore W36218318C2989005 @default.
• W36218318 hasConceptScore W36218318C31972630 @default.
• W36218318 hasConceptScore W36218318C37557685 @default.
• W36218318 hasConceptScore W36218318C41008148 @default.
• W36218318 hasConceptScore W36218318C42219234 @default.
• W36218318 hasConceptScore W36218318C42407357 @default.
• W36218318 hasConceptScore W36218318C71924100 @default.
• W36218318 hasConceptScore W36218318C82233179 @default.
• W36218318 hasLocation W362183181 @default.
• W36218318 hasOpenAccess W36218318 @default.
• W36218318 hasPrimaryLocation W362183181 @default.
• W36218318 hasRelatedWork W1564401469 @default.
• W36218318 hasRelatedWork W2013509661 @default.
• W36218318 hasRelatedWork W2018108351 @default.
• W36218318 hasRelatedWork W2163894595 @default.
• W36218318 hasRelatedWork W2171750224 @default.
• W36218318 hasRelatedWork W2246125075 @default.
• W36218318 hasRelatedWork W2277099365 @default.
• W36218318 hasRelatedWork W2553638895 @default.
• W36218318 hasRelatedWork W2753128467 @default.
• W36218318 hasRelatedWork W2996825079 @default.
• W36218318 hasRelatedWork W2997388725 @default.
• W36218318 hasRelatedWork W3033288009 @default.
• W36218318 hasRelatedWork W3114158167 @default.
• W36218318 hasRelatedWork W3133276089 @default.
• W36218318 hasRelatedWork W3172986220 @default.
• W36218318 hasRelatedWork W9516495 @default.
• W36218318 hasRelatedWork W98196018 @default.
• W36218318 hasRelatedWork W193443707 @default.
• W36218318 hasRelatedWork W2245489332 @default.
• W36218318 hasRelatedWork W2267721018 @default.
• W36218318 hasVolume "52" @default.
• W36218318 isParatext "false" @default.
• W36218318 isRetracted "false" @default.
• W36218318 magId "36218318" @default.
• W36218318 workType "article" @default.