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- W36224072 abstract "Publisher Summary To be useful in the detection of evolutionary relationships, a biochemical character should be poised between the extremes of biochemical unity and diversity. A character that would seem to meet this requirement is the mode of biosynthesis of the amino acid lysine. The two distinctive lysine pathways known to occur in nature can be considered as the molecular organelles that serve as “biochemical fossils.” α,ɛ-diaminopimelic acid (DAP) is a key intermediate in one of the pathways and α-aminoadipic acid (AAA) in the other. The major features of these biosynthetic systems have been established. The occurrence of the two lysine pathways in the biological world can be explored with the aid of certain specifically labeled radioactive tracers. The descent of the lysine paths correlates with major lines of evolution. The DAP path would seem to be a plant-like organelle; the inability to produce lysine may be an animal-like quality. However, the AAA path is a feature of organisms that have veered from the mainstream of evolution of the plant kingdom in the direction of the animal kingdom. These results recommend the character lysine synthesis as a phylogenetic tracer that complements other “biochemical fossils” as well as the non-biochemical characters of useful scope." @default.
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- W36224072 date "1965-01-01" @default.
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- W36224072 title "Lysine Biosynthesis and Evolution" @default.
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