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- W36245883 abstract "Experimental animal studies have demonstrated that changes occur in T1 and T2 relaxation, proton density and flow signal as a result of myocardial infarction and reperfusion [1, 2]. These parameters are mainly responsible for the changes in signal intensity on the magnetic resonance (MR) images. The change in signal intensity produced by myocardial ischemia is less than with infarction, and an MR contrast agent is usually required to enhance image contrast between ischemic and normal myocardium [3]. The ability of MR imaging to separate the various acute coronary syndromes has been addressed [4, 5], but requires further experimentation [4]. The purpose of this chapter is to examine the experimental data that is presently available regarding myocardial ischemia, infarction and reperfusion, and to indicate how these studies can be helpful in enhancing the potential of MR imaging for the characterization of coronary artery disease in the human subject. Already, it has been clearly demonstrated that recent myocardial infarction can be distinguished in humans and some estimation of the size of the infarction can be made [6, 7, 8]. The ability to differentiate viable from nonviable myocardium, and the place of MR contrast agents in helping to distinguish these conditions will require further animal experimentation. These studies will be useful in determining the place of MR imaging in the assessment of patients following acute myocardial ischemic events." @default.
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- W36245883 date "1991-01-01" @default.
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- W36245883 title "Magnetic resonance imaging of myocardial ischemia and infarction in experimental animal models" @default.
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- W36245883 doi "https://doi.org/10.1007/978-94-011-3772-0_7" @default.
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