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- W362714351 abstract "OBJECTIVE: The vulnerability of the brain is Considered to be increased after trauma. The present study was undertaken to determine whether intracranial volume insults in the posttraumatic period led to increased metabolic disturbances if intracranial compliance was decreased. METHODS: A weight drop technique with a brain compression of 1.5 mm was used for injury. Intracranial compensatory volume was decreased 60 mu l by placing rubber film between the dura mater and the bone. Intracranial volume insults were induced using the Bolus injection technique. Microdialysis was used to measure interstitial lactate, pyruvate, hypoxanthine, and glycerol. Fifty-two-rats Were allocated to trauma and sham groups with 0 to 3 layers of rubber film with and without intracranial volume insults. RESULTS: In the groups with reduced intracranial volume exposed to intracranial volume insults, the time course of metabolic markers showed higher increases and slower recovery rates than for the other groups. Reduced intracranial volume or intracranial volume insults alone did not cause any changes compared with controls. CONCLUSION: These results support the hypothesis that decreased intracranial compliance increases the vulnerability of the brain for secondary volume insults even with intracranial pressure at low levels between the insults. This finding has important clinical implications in that it stresses the need to identify patients with low intracranial compliance so that their treatment can be optimized." @default.
- W362714351 created "2016-06-24" @default.
- W362714351 creator A5001847765 @default.
- W362714351 date "2006-01-01" @default.
- W362714351 modified "2023-09-24" @default.
- W362714351 title "Intracranial Compliance and Secondary Brain Damage. Experimental and Clinical Studies in Traumatic Head Injury" @default.
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