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- W36292223 abstract "This brief review of fertility after the end of oral contraceptive therapy is highlighted by a discussion of the data for Norinyl-I (1 mg norethindrone 50 mcg mestranol). The drug was taken for more than 100000 cycles over the space of more than 4 years. 220 pregnancies were reported by patients who discontinued treatment either voluntarily or inadvertently. Among the patients who discontinued after treatment for 1 year or less 49% conceived within 3 months after end of therapy 75% within 6 months 89% within 12 months and 99% within 24 months. The data are similar for patients who discontinued after 2 3 and 4 years. It appears that the interval between therapy end and subsequent ovulation is comparable to the postpartum interval between delivery and return of fertility. Seemingly the hypothalamic-pituitary axis is suppressed either by pregnancy or by exogenous steroids the ovulatory function sometimes returning only gradually after delivery or discontinuation of the pill. Fertility per se is neither enhanced nor impaired following Norinyl-I therapy." @default.
- W36292223 created "2016-06-24" @default.
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- W36292223 date "1968-10-01" @default.
- W36292223 modified "2023-09-23" @default.
- W36292223 title "Oral contraception and future fertility." @default.
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