FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W362991299> ?p ?o ?g. }

• W362991299 abstract "Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. We have demonstrated that the transcriptional TNFα-inhibitor MDL 201,449A, previously shown to reduce immune-mediated diabetes induced in mice by multiple low doses of streptozotocin, was not TNFα-specific, but also inhibited IFNγ and IL-10 in spleen cells. Furthermore, when the inhibitor was removed from in vitro cultures, a rebound phenomenon of increased cytokine secretion occurred. The thesis also investigated whether plastic adhesion, a method generally employed to deplete macrophages, influenced cytokine production in spleen cells. We observed that plastic adhesion increased TNFα, IFNγ and IL-10 release, and decreased IL-4 secretion. Plastic adhesion depleted only ~30% of the macrophages, but as much as ~60% of the regulatory T cells. Thirdly, we found that “control” treatments for islet transplantations, i.e. syngeneic and sham transplantations, exerted a clear effect on cytokine production from spleen cells, possibly due to a decrease in regulatory T cells that may be caused by the surgery and/or anaesthesia. Moreover, spleen cells from mice exposed to surgery exhibited a decreased proliferative capacity to concanavalin A stimulation. We also perceived a marked difference in cytokine response depending on the mouse strain used in the experiments. Finally, we aimed to elucidate if, besides autoimmune activities, also high glucose- and free fatty acid concentrations as seen in diabetes could cause changes in cytokine production. We observed that spleen cells cultured in varying glucose concentrations had different cytokine production profiles. The free fatty acid palmitate might also influence cytokine release, but this effect was obscured by the cytokine-suppressive action of the ethanol used to dissolve the palmitate." @default.
• W362991299 created "2016-06-24" @default.
• W362991299 creator A5043761463 @default.
• W362991299 date "2011-06-13" @default.
• W362991299 modified "2023-09-23" @default.
• W362991299 title "Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus" @default.
• W362991299 cites W146682373 @default.
• W362991299 cites W1484840368 @default.
• W362991299 cites W1485442318 @default.
• W362991299 cites W1489740257 @default.
• W362991299 cites W1505646153 @default.
• W362991299 cites W1521047668 @default.
• W362991299 cites W1567420244 @default.
• W362991299 cites W1575585006 @default.
• W362991299 cites W1590974138 @default.
• W362991299 cites W1592749565 @default.
• W362991299 cites W1806303658 @default.
• W362991299 cites W1813966714 @default.
• W362991299 cites W1853287186 @default.
• W362991299 cites W1860396379 @default.
• W362991299 cites W1891716380 @default.
• W362991299 cites W1914199395 @default.
• W362991299 cites W1931297840 @default.
• W362991299 cites W1935867447 @default.
• W362991299 cites W1938589063 @default.
• W362991299 cites W1963749512 @default.
• W362991299 cites W1969345176 @default.
• W362991299 cites W1970177030 @default.
• W362991299 cites W1970327800 @default.
• W362991299 cites W1974089457 @default.
• W362991299 cites W1975363851 @default.
• W362991299 cites W1975586412 @default.
• W362991299 cites W1983278883 @default.
• W362991299 cites W1984570403 @default.
• W362991299 cites W1985710633 @default.
• W362991299 cites W1986346567 @default.
• W362991299 cites W1986663147 @default.
• W362991299 cites W1989090634 @default.
• W362991299 cites W1989845413 @default.
• W362991299 cites W1989925698 @default.
• W362991299 cites W1990356591 @default.
• W362991299 cites W1990757970 @default.
• W362991299 cites W1991846489 @default.
• W362991299 cites W1992847158 @default.
• W362991299 cites W1996909141 @default.
• W362991299 cites W1998065531 @default.
• W362991299 cites W1998572804 @default.
• W362991299 cites W1998952160 @default.
• W362991299 cites W2002726823 @default.
• W362991299 cites W2004185349 @default.
• W362991299 cites W2005040360 @default.
• W362991299 cites W2008047545 @default.
• W362991299 cites W2010357177 @default.
• W362991299 cites W2010367326 @default.
• W362991299 cites W2011194726 @default.
• W362991299 cites W2011659919 @default.
• W362991299 cites W2012275514 @default.
• W362991299 cites W2012944711 @default.
• W362991299 cites W2014251944 @default.
• W362991299 cites W2017934798 @default.
• W362991299 cites W2018039307 @default.
• W362991299 cites W2019502698 @default.
• W362991299 cites W2019984014 @default.
• W362991299 cites W2021162850 @default.
• W362991299 cites W2021603971 @default.
• W362991299 cites W2021713059 @default.
• W362991299 cites W2024670462 @default.
• W362991299 cites W2025444976 @default.
• W362991299 cites W2028068170 @default.
• W362991299 cites W2028212562 @default.
• W362991299 cites W2028646404 @default.
• W362991299 cites W2029870728 @default.
• W362991299 cites W2031501484 @default.
• W362991299 cites W2031873118 @default.
• W362991299 cites W2033986343 @default.
• W362991299 cites W2034637422 @default.
• W362991299 cites W2035116554 @default.
• W362991299 cites W2036329920 @default.
• W362991299 cites W2036688779 @default.
• W362991299 cites W2037597809 @default.
• W362991299 cites W2039937531 @default.
• W362991299 cites W2041591721 @default.
• W362991299 cites W2042227130 @default.
• W362991299 cites W2043950995 @default.
• W362991299 cites W2044210379 @default.
• W362991299 cites W2047399305 @default.
• W362991299 cites W2047851865 @default.
• W362991299 cites W2048211245 @default.
• W362991299 cites W2048994961 @default.
• W362991299 cites W2053330926 @default.
• W362991299 cites W2055818786 @default.
• W362991299 cites W2056406633 @default.
• W362991299 cites W2056517528 @default.
• W362991299 cites W2057123987 @default.
• W362991299 cites W2063921739 @default.
• W362991299 cites W2066702528 @default.
• W362991299 cites W2067387741 @default.
• W362991299 cites W2069898576 @default.
• W362991299 cites W2070696234 @default.
• W362991299 cites W2070895254 @default.

• next