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- W363419720 abstract "One of the problems in reviewing the field of immunogenetics and host response to parasites just now is that most genetic studies undertaken to date have been underpowered. This chapter discusses complexity and heritability of parasitic disease susceptibility, and how study design is evolving to provide diseases like parasitic infections. With the advent of technologies that allow upwards of 500,000 single nucleotide polymorphisms (SNPs) to be assayed simultaneously, the so-called “SNP-chip” technology, genome-wide association study (GWAS) have become possible. Recent interest has focused on the role of innate immunity in driving the adaptive immune response, particularly in relation to intramacrophage pathogens. The outcome of infection with pathogenic parasites is complex, that multiple genes can be expected to influence susceptibility to disease. Many future studies for parasitic diseases can be expected to provide a wealth of new data that can seed many novel functional studies on mechanisms of disease that can be translated into better interventions for the future." @default.
- W363419720 created "2016-06-24" @default.
- W363419720 creator A5074203084 @default.
- W363419720 date "2014-04-30" @default.
- W363419720 modified "2023-09-23" @default.
- W363419720 title "Immunogenetics of Host Response to Parasites in Humans" @default.
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- W363419720 doi "https://doi.org/10.1128/9781555816872.ch38" @default.
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