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- W36355389 abstract "AIM: To investigate the role of cytokine gene expression inorgan damage at different tissue sites during sepsis.METHODS: Male NIH mice were subjected to cecal ligationand puncture (CLP) or sham operetion ( Sham ). Pro-inflammatory cytokine (TNFα, IL-1β and IL-6) and anti-inflammatory cytokine (IL-4) gene expression in the liverand lung tissue were assessed by RT-PCR. The permeabilityof microvascular and water content in the lungs and liverwere also examined.RESULTS: Significant increase in TNFα, IL-1β and IL-6 geneexpression was observed at 3 and 12 h after CLP both in theliver and lungs ( P＜ 0.01). The level of IL-4 gene expressionwas not changed after CLP in the lungs, but increased at 12h after CLP ( P ＜ 0.01) in the liver tissue. Both the liver andlungs showed a significant increase in microcirculatorypermeability at 12 h after CLP (P＜ 0.01), and the increasein the lungs was higher than that in the liver. The watermaes fractions in the liver ( P＜ 0.05) and lungs ( P＜ 0.01)were increased after CLP, and the increase in the lungshappened earlier and more severely than that in the liver.CONCLUSION: The inflammatory response in the liver andlungs wes different during sepsis. At the early stage ofsepsis, pro-inflammatory reaction dominates both in theliver and lungs. But at the later stage of sepsis, induction ofcompensatory anti-inflammatory response was seen in theliver but not in the lungs. This difference in situ activity maycontribute to the different vulnerability of organ damageduring sepsis. The strategy of systemic administration ofanti-inflammatory drugs to sepsis should be reconsidered." @default.
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- W36355389 date "2002-01-01" @default.
- W36355389 modified "2023-09-23" @default.
- W36355389 title "Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture" @default.
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