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- W364100206 abstract "This chapter provides a brief synopsis of the natural history of paralytic poliomyelitis, and gives an overview of the status of research concerning the molecular determinants of the pathogenesis of paralytic poliomyelitis. Determinants of the pathogenesis of poliomyelitis are either of viral origin, e.g., non-coding viral sequences, structural or nonstructural viral gene products, or of host origin, e.g., distribution of the cellular receptor and host cell factors required for viral replication. To provide a rational account of the relative contributions of a multitude of factors toward a complex phenomenon, the chapter is subdivided into sections dealing with the main parameters of poliovirus neurological disease. Tropism, neurovirulence, and conditions of the host are discussed separately. The chapter discusses experimental evidence for the genetic basis of neurovirulence in the 5∇ non-translated region (5' NTR) and the coding regions for the structural and nonstructural proteins of poliovirus. Extraneural determinants of neuropathogenicity, such as invasion of or spread within the CNS, combine with intraneural factors, such as IRES-mediated cell type specificity or the efficiency of genome replication. Excellent studies in nonhuman primates in the prevaccine era and recent progress through the advent of genetic engineering and transgenic animal models for human disease have afforded us detailed insight into the pathogenic mechanism of paralytic poliomyelitis." @default.
- W364100206 created "2016-06-24" @default.
- W364100206 creator A5035967827 @default.
- W364100206 creator A5064761966 @default.
- W364100206 date "2014-04-23" @default.
- W364100206 modified "2023-10-16" @default.
- W364100206 title "Determinants of Poliovirus Pathogenesis" @default.
- W364100206 cites W123540556 @default.
- W364100206 cites W143205737 @default.
- W364100206 cites W1518959069 @default.
- W364100206 cites W1521859923 @default.
- W364100206 cites W1525347922 @default.
- W364100206 cites W1529709430 @default.
- W364100206 cites W1535419237 @default.
- W364100206 cites W1550146591 @default.
- W364100206 cites W1554853998 @default.
- W364100206 cites W1567952953 @default.
- W364100206 cites W1583174248 @default.
- W364100206 cites W1606976916 @default.
- W364100206 cites W1615118177 @default.
- W364100206 cites W1641036754 @default.
- W364100206 cites W1670248086 @default.
- W364100206 cites W1673403739 @default.
- W364100206 cites W1708365360 @default.
- W364100206 cites W1807212217 @default.
- W364100206 cites W1847574526 @default.
- W364100206 cites W1853272854 @default.
- W364100206 cites W1866802553 @default.
- W364100206 cites W1901014599 @default.
- W364100206 cites W1923030653 @default.
- W364100206 cites W1926080361 @default.
- W364100206 cites W1951570756 @default.
- W364100206 cites W1957562975 @default.
- W364100206 cites W1958691693 @default.
- W364100206 cites W1963206119 @default.
- W364100206 cites W1963803182 @default.
- W364100206 cites W1963995395 @default.
- W364100206 cites W1964656657 @default.
- W364100206 cites W1965390534 @default.
- W364100206 cites W1966587932 @default.
- W364100206 cites W1969735970 @default.
- W364100206 cites W1970725479 @default.
- W364100206 cites W1975456996 @default.
- W364100206 cites W1980696302 @default.
- W364100206 cites W1986992353 @default.
- W364100206 cites W1987898030 @default.
- W364100206 cites W1987977026 @default.
- W364100206 cites W1988766125 @default.
- W364100206 cites W1991536902 @default.
- W364100206 cites W1991624039 @default.
- W364100206 cites W1993756781 @default.
- W364100206 cites W1997221411 @default.
- W364100206 cites W1998922807 @default.
- W364100206 cites W2001070008 @default.
- W364100206 cites W2004670971 @default.
- W364100206 cites W2007728734 @default.
- W364100206 cites W2010004911 @default.
- W364100206 cites W2010235249 @default.
- W364100206 cites W2013855627 @default.
- W364100206 cites W2017093959 @default.
- W364100206 cites W2017307573 @default.
- W364100206 cites W2018585471 @default.
- W364100206 cites W2026608391 @default.
- W364100206 cites W2028523627 @default.
- W364100206 cites W2034256660 @default.
- W364100206 cites W2039679745 @default.
- W364100206 cites W2040559866 @default.
- W364100206 cites W2042814927 @default.
- W364100206 cites W2044967254 @default.
- W364100206 cites W2047157488 @default.
- W364100206 cites W2048258437 @default.
- W364100206 cites W2048731469 @default.
- W364100206 cites W2050956922 @default.
- W364100206 cites W2051758487 @default.
- W364100206 cites W2053891047 @default.
- W364100206 cites W2060361076 @default.
- W364100206 cites W2063112040 @default.
- W364100206 cites W2063826038 @default.
- W364100206 cites W2065392104 @default.
- W364100206 cites W2070800925 @default.
- W364100206 cites W2072397017 @default.
- W364100206 cites W2078539040 @default.
- W364100206 cites W2083559305 @default.
- W364100206 cites W2092019188 @default.
- W364100206 cites W2093684485 @default.
- W364100206 cites W2095353564 @default.
- W364100206 cites W2095989475 @default.
- W364100206 cites W2097446370 @default.
- W364100206 cites W2104799220 @default.
- W364100206 cites W2109715765 @default.
- W364100206 cites W2117837310 @default.
- W364100206 cites W2121253082 @default.
- W364100206 cites W2126849784 @default.
- W364100206 cites W2127528304 @default.
- W364100206 cites W2153903656 @default.
- W364100206 cites W2167102696 @default.
- W364100206 cites W2409471903 @default.
- W364100206 cites W2439298745 @default.