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- W36503859 abstract "A hypothesis of the possible role of Epstein-Barr virus (EBV) in the etiology of atherosclerosis has been proposed almost 30 years ago. The possible mechanisms of this connection can include induction and/or promotion of the proliferation of artery wall intimal smooth muscle cells by inflammatory injury or induction of genomic alterations leading to clonal expansion of intimal smooth muscle cell populations. In this review, we analyzed the feasible association between EBV and atherosclerosis. The results of certain investigators support the point of view that EBV-infection may influence the development of atherosclerosis; however, the majority of studies disprove this hypothesis. Almost all the studies where the positive association was found should not be established as entirely credible. Moreover, contradicting results were observed even in the same populations that refutes the hypothesis about the population dependence on the association between EBV and atherosclerosis. On the whole, the situation with the feasible association between EBV and atherosclerosis seems to be following: albeit there is a number of basic mechanisms supporting this hypothesis, current epidemiological data do not evidence in favor of this association. At the moment, it is not possible to establish EBV as a probable causative agent of atherosclerosis until reliable epidemiological studies devoted to the problem will confirm this hypothesis." @default.
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- W36503859 date "2013-01-01" @default.
- W36503859 modified "2023-09-23" @default.
- W36503859 title "The Role of Epstein-Barr Virus in Atherosclerosis and Related Diseases" @default.
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- W36503859 doi "https://doi.org/10.1007/978-1-4614-8863-7_3" @default.
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