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- W365041386 abstract "Normal pancreatic juice contains <1 mM concentrations of Ca2+, but little is known about Ca2+ homeostasis, which may be an important function of duct epithelium. Our aim was to investigate whether duct cells from human and rat pancreas express Ca2+-transporting and Ca2+-binding proteins and whether purinergic receptors regulate Ca2+ transport, as is known for anion transport. Expression analysis revealed that pancreatic ducts of rat and human duct cell line CFPAC-1 (also PANC-1 and Capan-1) express the Na+/Ca2+ exchanger (NCX), as well as the Ca2+-sensing receptor and the Ca2+-binding protein calbindin 9kD. These proteins localize to the luminal and lateral membranes of pancreatic duct epithelia. Ca2+ imaging experiments showed that activation of purinergic P2X and P2Y receptors stimulated NCX in rat and human duct cells. Application of ATP to CFPAC-1 monolayers stimulated Ca2+ transport from the luminal to the basolateral side. Taken together, these results show that pancreatic ducts express a number of Ca2+-handling proteins and we suggest that these together with purinergic receptors may play a role in regulation of pancreatic Ca2+ transport. Support: PhD scholarship, University of Copenhagen and DNSRC 272-05-0420" @default.
- W365041386 created "2016-06-24" @default.
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- W365041386 date "2009-04-01" @default.
- W365041386 modified "2023-09-27" @default.
- W365041386 title "Purinergic receptors stimulate Calcium transport in pancreatic duct cells" @default.
- W365041386 doi "https://doi.org/10.1096/fasebj.23.1_supplement.796.18" @default.
- W365041386 hasPublicationYear "2009" @default.
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