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- W36555794 abstract "This chapter discusses immune complex diseases. The localization of the tissue damage depends primarily on where the antigen–antibody reaction takes place, while the severity is related to the amount of complexes produced. If the antigen is localized in a certain tissue, the antibody binds to it resulting in local damage. If the antigen–antibody complexes form in the circulation, they have a tendency to localize in structures that function as physiological filters. A good example of immune complex induced tissue damage is the Arthu's reaction, which is a localized, acute, necrotizing vasculitis. One of the reactants, antigen or antibody, must be present in the circulation and the other one is injected locally. The produced antigen–antibody complexes are deposited in local vessels and react with complement. Granulocytes move in by chemotaxis. Phagocytosis and degradation of the immune complexes and release of toxic material from the granules of the phagocytes, together with free radicals from the cell-membrane follow, resulting in inflammatory changes in the vessel walls. Circulating soluble antigen–antibody complexes are most easily formed in the presence of an excess of multivalent antigens. The amount of antigen and the period of time the antigen is present in the circulation is of importance for the development of the tissue damage." @default.
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- W36555794 date "1985-01-01" @default.
- W36555794 modified "2023-09-27" @default.
- W36555794 title "Immune complex diseases" @default.
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- W36555794 doi "https://doi.org/10.1016/b978-0-407-00372-9.50023-7" @default.
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