FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W365566> ?p ?o ?g. }

• W365566 endingPage "23" @default.
• W365566 startingPage "9" @default.
• W365566 abstract "Clusterin (CLU) has kept many researchers engaged for a long time since its first discovery and characterization in the attempt to unravel its biological role in mammals. Although there is a general consensus on the fact that CLU is supposed to play important roles in nearly all fundamental biological phenomena and in many human diseases including cancer, after about 10 years of work CLU has been defined as an enigmatic protein. This sense of frustration among the researchers is originated by the fact that, despite considerable scientific production concerning CLU, there is still a lack of basic information about the complex regulation of its expression. The CLU gene is a single 9-exon gene expressed at very different levels in almost all major tissues in mammals. The gene produces at least three protein forms with different subcellular localization and diverse biological functions. The molecular mechanism of production of these protein forms remains unclear. The best known is the glycosylated mature form of CLU (sCLU), secreted with very big quantitative differences at different body sites. Hormones and growth factors are the most important regulators of CLU gene expression. Before 2006, it was believed that a unique transcript of about 1.9 kb was originated by transcription of the CLU gene. Now we know that alternative transcriptional initiation, possibly driven by two distinct promoters, may produce at least two distinct CLU mRNA isoforms differing in their unique first exon, named Isoform 1 and Isoform 2. A third transcript, named Isoform 11036, has been recently found as one of the most probable mRNA variants. Approaches like cloning, expression, and functional characterization of the different CLU protein products have generated a critical mass of information teaching us an important lesson about CLU gene expression regulation. Nevertheless, further studies are necessary to better understand the tissue-specific regulation of CLU expression and to identify the specific signals triggering the expression of different/alternative transcript isoforms and protein forms in different cell types at appropriate time." @default.
• W365566 created "2016-06-24" @default.
• W365566 creator A5020575257 @default.
• W365566 creator A5054152206 @default.
• W365566 creator A5084682964 @default.
• W365566 date "2009-01-01" @default.
• W365566 modified "2023-10-06" @default.
• W365566 title "Chapter 2 Clusterin (CLU)" @default.
• W365566 cites W1508035463 @default.
• W365566 cites W1672583421 @default.
• W365566 cites W1835061903 @default.
• W365566 cites W1925698292 @default.
• W365566 cites W1965837532 @default.
• W365566 cites W1967618835 @default.
• W365566 cites W1969321512 @default.
• W365566 cites W1970233304 @default.
• W365566 cites W1976229755 @default.
• W365566 cites W1976945780 @default.
• W365566 cites W1981823633 @default.
• W365566 cites W1986234009 @default.
• W365566 cites W1988633030 @default.
• W365566 cites W1988710162 @default.
• W365566 cites W1990481620 @default.
• W365566 cites W1991920961 @default.
• W365566 cites W1993618969 @default.
• W365566 cites W1994397710 @default.
• W365566 cites W1994617703 @default.
• W365566 cites W1996945731 @default.
• W365566 cites W1998262721 @default.
• W365566 cites W2001793259 @default.
• W365566 cites W2002029439 @default.
• W365566 cites W2008099973 @default.
• W365566 cites W2010096155 @default.
• W365566 cites W2013121814 @default.
• W365566 cites W2013168510 @default.
• W365566 cites W2014921813 @default.
• W365566 cites W2015461092 @default.
• W365566 cites W2019903573 @default.
• W365566 cites W2019906171 @default.
• W365566 cites W2027444024 @default.
• W365566 cites W2029031761 @default.
• W365566 cites W2031719598 @default.
• W365566 cites W2035648934 @default.
• W365566 cites W2038035925 @default.
• W365566 cites W2046462560 @default.
• W365566 cites W2048496806 @default.
• W365566 cites W2049119567 @default.
• W365566 cites W2054145760 @default.
• W365566 cites W2055406929 @default.
• W365566 cites W2061209448 @default.
• W365566 cites W2062875562 @default.
• W365566 cites W2066601410 @default.
• W365566 cites W2071064041 @default.
• W365566 cites W2071306117 @default.
• W365566 cites W2071368489 @default.
• W365566 cites W2073862947 @default.
• W365566 cites W2074451990 @default.
• W365566 cites W2084528656 @default.
• W365566 cites W2112382919 @default.
• W365566 cites W2114738562 @default.
• W365566 cites W2121135241 @default.
• W365566 cites W2128350634 @default.
• W365566 cites W2130296644 @default.
• W365566 cites W2137299591 @default.
• W365566 cites W2142409690 @default.
• W365566 cites W2152684385 @default.
• W365566 cites W2153550523 @default.
• W365566 cites W2155198986 @default.
• W365566 cites W2158173168 @default.
• W365566 cites W2166575679 @default.
• W365566 cites W2171011502 @default.
• W365566 cites W2340073049 @default.
• W365566 cites W35197623 @default.
• W365566 cites W4229568396 @default.
• W365566 cites W94651834 @default.
• W365566 doi "https://doi.org/10.1016/s0065-230x(09)04002-0" @default.
• W365566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19878770" @default.
• W365566 hasPublicationYear "2009" @default.
• W365566 type Work @default.
• W365566 sameAs 365566 @default.
• W365566 citedByCount "41" @default.
• W365566 countsByYear W3655662012 @default.
• W365566 countsByYear W3655662013 @default.
• W365566 countsByYear W3655662014 @default.
• W365566 countsByYear W3655662015 @default.
• W365566 countsByYear W3655662016 @default.
• W365566 countsByYear W3655662017 @default.
• W365566 countsByYear W3655662018 @default.
• W365566 countsByYear W3655662019 @default.
• W365566 countsByYear W3655662020 @default.
• W365566 countsByYear W3655662021 @default.
• W365566 countsByYear W3655662022 @default.
• W365566 countsByYear W3655662023 @default.
• W365566 crossrefType "book-chapter" @default.
• W365566 hasAuthorship W365566A5020575257 @default.
• W365566 hasAuthorship W365566A5054152206 @default.
• W365566 hasAuthorship W365566A5084682964 @default.
• W365566 hasConcept C101762097 @default.

• next