Matches in SemOpenAlex for { <https://semopenalex.org/work/W36557223> ?p ?o ?g. }
- W36557223 endingPage "78" @default.
- W36557223 startingPage "51" @default.
- W36557223 abstract "G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are transmembrane receptors that initiate intracellular signaling cascades in response to a diverse array of ligands. Recent studies have shown that signal transduction initiated by GPCRs and RTKs is not organized in distinct signaling cassettes where receptor activation leads to cell division and gene transcription in a linear manner. In fact, signal integration and diversification arises from a complex network involving crosscommunication between separate signaling units. Several different styles of crosstalk between GPCR- and RTK-initiated pathways exist, with GPCRs or components of GPCR-induced pathways being either upstream or downstream of RTKs. Activation of GPCRs sometimes results in a phenomenon known as transactivation of RTKs, which leads to the recruitment of scaffold proteins, such as Shc, Grb2, and Sos in addition to mitogen-activated protein kinase activation. In other cases, RTKs use different components of GPCR-mediated signaling, such as beta-arrestin, G protein-receptor kinases, and regulator of G protein signaling to integrate signaling pathways. This chapter outlines some of the more common mechanisms used by both GPCRs and RTKs to initiate intracellular crosstalk, thereby creating a complex signaling network that is important to normal development." @default.
- W36557223 created "2016-06-24" @default.
- W36557223 creator A5003632963 @default.
- W36557223 creator A5074200940 @default.
- W36557223 date "2006-09-07" @default.
- W36557223 modified "2023-09-28" @default.
- W36557223 title "Crosstalk Coregulation Mechanisms of G Protein-Coupled Receptors and Receptor Tyrosine Kinases" @default.
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