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- W366157299 abstract "Cryptosporidium parvum is a protozoan parasite that infects the intestinal epithelial cells (IECs). Dendritic cells (DCs) are professional antigen-presenting cells. DCs in the intestine can capture antigens and may contribute to tolerance, or to the generation of specific immune responses. Nothing is known about their role in neonatal cryptosporidiosis. Myeloid DCs respond to contact the parasite by overexpressing the coactivation molecules CD40, CD80 and CD86 and MHC class II molecules at their surface and by producing IL-12 in a TLR-4 dependant way. We then studied the recruitment and activation of DCs in vivo in a newborn mouse model. All the DC-attracting chemokines studied were also up-regulated except CCL20. Immunohistochemical staining showed that DCs were recruited to the lamina propia and the MLN of infected mice. Myeloid DCs and double-negative DCs were the two subpopulations most strongly recruited." @default.
- W366157299 created "2016-06-24" @default.
- W366157299 creator A5021094966 @default.
- W366157299 date "2007-01-01" @default.
- W366157299 modified "2023-09-23" @default.
- W366157299 title "La cryptosporidiose du nouveau-né : étude des cellules dendritiques" @default.
- W366157299 hasPublicationYear "2007" @default.
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