Matches in SemOpenAlex for { <https://semopenalex.org/work/W36618923> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W36618923 endingPage "1472" @default.
- W36618923 startingPage "1468" @default.
- W36618923 abstract "Summary Plasma levels of blood coagulation zymogens are lower in the newborn than in the adult, with the lowest levels being in preterm infants. It is not known if the lower coagulation factor levels reflect differences in synthesis, secretion or catabolism. Using a rabbit model we have compared prothrombin synthesis in the fetus and adult. In previous studies we attempted to compare transcription in the adult and fetal liver by extraction of mRNA, immobilization on a membrane and hybridization with a labeled cDNA for rabbit prothrombin. Comparison was impaired by the markedly dissimilar composition of fetal and adult rabbit liver; fetal liver is approximately fifty percent hematopoietic tissue even at term (1). In the present study, to obtain a more meaningful comparison we have employed in situ hybridization to compare directly prothrombin expression in adult and fetal liver. We report here that fetal liver contains more prothrombin mRNA than does adult liver. We have further compared prothrombin levels in protein extracts of adult and fetal liver and found that per microgram of extract, fetal liver contains as much prothrombin as does the adult. We conclude that the lower plasma prothrombin levels in the fetus do not reflect a lower rate of synthesis." @default.
- W36618923 created "2016-06-24" @default.
- W36618923 creator A5000534322 @default.
- W36618923 creator A5007132576 @default.
- W36618923 creator A5043762116 @default.
- W36618923 creator A5071224313 @default.
- W36618923 creator A5079502494 @default.
- W36618923 creator A5086704674 @default.
- W36618923 creator A5088340058 @default.
- W36618923 date "1997-01-01" @default.
- W36618923 modified "2023-10-01" @default.
- W36618923 title "Prothrombin Synthesis in the Adult and Fetal Liver" @default.
- W36618923 doi "https://doi.org/10.1055/s-0038-1665435" @default.
- W36618923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9423796" @default.
- W36618923 hasPublicationYear "1997" @default.
- W36618923 type Work @default.
- W36618923 sameAs 36618923 @default.
- W36618923 citedByCount "5" @default.
- W36618923 crossrefType "journal-article" @default.
- W36618923 hasAuthorship W36618923A5000534322 @default.
- W36618923 hasAuthorship W36618923A5007132576 @default.
- W36618923 hasAuthorship W36618923A5043762116 @default.
- W36618923 hasAuthorship W36618923A5071224313 @default.
- W36618923 hasAuthorship W36618923A5079502494 @default.
- W36618923 hasAuthorship W36618923A5086704674 @default.
- W36618923 hasAuthorship W36618923A5088340058 @default.
- W36618923 hasConcept C126322002 @default.
- W36618923 hasConcept C134018914 @default.
- W36618923 hasConcept C144594695 @default.
- W36618923 hasConcept C16685009 @default.
- W36618923 hasConcept C172680121 @default.
- W36618923 hasConcept C2777292125 @default.
- W36618923 hasConcept C2778382381 @default.
- W36618923 hasConcept C2779234561 @default.
- W36618923 hasConcept C2780434524 @default.
- W36618923 hasConcept C2780930249 @default.
- W36618923 hasConcept C54355233 @default.
- W36618923 hasConcept C62231903 @default.
- W36618923 hasConcept C71924100 @default.
- W36618923 hasConcept C86803240 @default.
- W36618923 hasConcept C89560881 @default.
- W36618923 hasConcept C96942376 @default.
- W36618923 hasConceptScore W36618923C126322002 @default.
- W36618923 hasConceptScore W36618923C134018914 @default.
- W36618923 hasConceptScore W36618923C144594695 @default.
- W36618923 hasConceptScore W36618923C16685009 @default.
- W36618923 hasConceptScore W36618923C172680121 @default.
- W36618923 hasConceptScore W36618923C2777292125 @default.
- W36618923 hasConceptScore W36618923C2778382381 @default.
- W36618923 hasConceptScore W36618923C2779234561 @default.
- W36618923 hasConceptScore W36618923C2780434524 @default.
- W36618923 hasConceptScore W36618923C2780930249 @default.
- W36618923 hasConceptScore W36618923C54355233 @default.
- W36618923 hasConceptScore W36618923C62231903 @default.
- W36618923 hasConceptScore W36618923C71924100 @default.
- W36618923 hasConceptScore W36618923C86803240 @default.
- W36618923 hasConceptScore W36618923C89560881 @default.
- W36618923 hasConceptScore W36618923C96942376 @default.
- W36618923 hasIssue "06" @default.
- W36618923 hasLocation W366189231 @default.
- W36618923 hasLocation W366189232 @default.
- W36618923 hasOpenAccess W36618923 @default.
- W36618923 hasPrimaryLocation W366189231 @default.
- W36618923 hasRelatedWork W2046997719 @default.
- W36618923 hasRelatedWork W2078416978 @default.
- W36618923 hasRelatedWork W2314088461 @default.
- W36618923 hasRelatedWork W2330625864 @default.
- W36618923 hasRelatedWork W2366308376 @default.
- W36618923 hasRelatedWork W2399667947 @default.
- W36618923 hasRelatedWork W2407434454 @default.
- W36618923 hasRelatedWork W2770435532 @default.
- W36618923 hasRelatedWork W36618923 @default.
- W36618923 hasRelatedWork W4301512355 @default.
- W36618923 hasVolume "78" @default.
- W36618923 isParatext "false" @default.
- W36618923 isRetracted "false" @default.
- W36618923 magId "36618923" @default.
- W36618923 workType "article" @default.