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- W36639770 abstract "This chapter presents comments on triggering and tolerance of cells. The fact that B cells can be turned on to immunoglobulin synthesis by polyclonal B cell activators (PBA) clearly shows that triggering can occur without any participation of Ig receptors. One experiment to clarify this is to add truly thymus-dependent antigens lacking PBA properties to B cells. This does not induce antibody synthesis or cause tolerance. Anti-idiotype antibodies also fail to activate B cells to the synthesis of the corresponding antibody in the absence of T cell help. The induction of immunological tolerance to thymus-independent antigens does not lead to elimination of the entire clone of specific B cells. The easy induction of autoantibodies by polyclonal B cell activators also argues against Ig receptors having a dominant role in tolerance induction. Although it has been found that B cells from newborn mice are more vulnerable than cells from adults, the demonstration that cells from adults can be induced to autoantibody synthesis shows that this mechanism is not sufficient to prevent the appearance of self-reactive clones later in life. The same B cells are activated and tolerized by contact with antigen." @default.
- W36639770 created "2016-06-24" @default.
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- W36639770 date "1980-01-01" @default.
- W36639770 modified "2023-10-05" @default.
- W36639770 title "TRIGGERING AND TOLERANCE" @default.
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- W36639770 doi "https://doi.org/10.1016/b978-0-12-637140-6.50077-2" @default.
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