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• W366899495 abstract "Nanoparticles are becoming promising carriers for gene delivery because of their high capacity in gene loading and low cell cytotoxicity. In this study, a chitosan-based nanoparticle encapsulated within a recombinant pcDNA3.1-dsNKG2D-IL-15 plasmid was generated. The fused dsNKG2D-IL-15 gene fragment consisted of double extracellular domains of NKG2D with IL-15 gene at downstream. The average diameter of the gene nanoparticles ranged from 200 nm to 400 nm, with mean zeta potential value of 53.8 ± 6.56 mV. The nanoparticles which were loaded with the dsNKG2D-IL-15 gene were uptaken by tumor cells with low cytotoxicity. Tumor cells pre-transfected by gene nanopartilces stimulated NK and T cells in vitro. Intramuscular injection of gene nanoparticles suppressed tumor growth and prolonged survival of tumor-bearing mice through activation of NK and CD8(+) T cells. Thus, chitosan-based nanoparticle delivery of dsNKG2D-IL-15 gene vaccine can be potentially used for tumor therapy." @default.
• W366899495 created "2016-06-24" @default.
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• W366899495 date "2015-07-01" @default.
• W366899495 modified "2023-10-14" @default.
• W366899495 title "Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity" @default.
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• W366899495 doi "https://doi.org/10.1016/j.bbrc.2015.05.065" @default.
• W366899495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26022121" @default.
• W366899495 hasPublicationYear "2015" @default.
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