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- W36697467 abstract "1616 Objectives: The purpose of this study was to evaluate the effects of hyperglycemia on FDG uptake of the brain, liver, muscle and tumor in clinical situation. Methods: Fifty-seven patients (mean age:64.8±8.9, range:42-79, male:female=40:17) who showed blood glucose level more than 200 mg/dl at the time of examination (mean glucose level:255.5±69.3, range:201-666) were included in this retrospective study. All patients received FDG-PET scan for suspected cancer in Kyoto University Hospital from January 2001 to December 2005 and fasted at least 4 hours before PET study. Reasons of hyperglycemia were follows; untreated diabetes: n=5, uncontrolled diabetes: n=32, unknown: n=20. FDG accumulation of the tumor was visually analyzed. SUV of the brain, liver, muscle and tumor were also analyzed. Results: Presence or absence of malignant lesion was confirmed by other modality such as CT, surgery, and clinical follow-up at least 6 month in 49 patients and malignant lesion(s) were finally diagnosed in 35 patients. Twenty eight of 35 patients had positive results by visual analysis (lung cancer:7, pancreas cancer:7, liver metastases:3, lung metastases:3, hepatocellular carcinoma:2, bone metastases:2, etc.) and the average of tumor SUV was 5.7±2.5. False negative results were observed in 7 cases which consisted of so-called low-FDG-avid tumors (hepatocellular carcinoma:3, pancreas cancer:3, small lung metastasis from pancreas cancer:1) and the average of tumor SUV was 2.7±0.8. In contrast to relatively stable tumor FDG uptake, brain FDG uptake tended to be lower in this high glucose level (SUV=4.4±1.1), as compared to that in normoglycemia (SUV=11.8±2.6). Liver, muscle and tumor FDG uptake didn’t show clear correlation with blood glucose level. Specificity, sensitivity and PPV of FDG-PET scan were 67%, 97% and 80% respectively. Conclusions: In spite of high blood glucose level (more than 200 mg/dl), FDG uptake of the tumor maintained enough high level for visual diagnosis in majority of cases, except for the cases of low-FDG-avid tumors, such as hepatocellular carcinoma and pancreas cancer." @default.
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- W36697467 date "2007-05-01" @default.
- W36697467 modified "2023-09-23" @default.
- W36697467 title "Clinical effects of hyperglycemia on FDG uptake of tumor and brain in patients with suspected cancer" @default.
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