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• W367035320 abstract "A brain drug delivery system for glioma chemotherapy based on transferrin and cell-penetrating peptide dual-functioned liposome, Tf/TAT-lip, was made and evaluated with doxorubicin (DOX) as a model drug. TAT conjugated liposome (TAT-lip) loaded with doxorubicin (DOX) were prepared by the thin film hydration methods (lip-DOX) and then conjugated with transferrin (Tf) to yield Tf/TAT-lip-DOX which was characterized for their various physicochemical and pharmaceutical properties. Cellular uptakes were explored in both brain capillary endothelial cells (BCECs) of rats and U87 cells. The blood brain barrier model in vitro was established to evaluate the trans-endothelial ability crossing the BBB. The biodistribution of each formulation was further identified. The Tf/TAT-lip-DOX presents the best anti-proliferative activity against U87 cells. The orthotropic glioma model was established for the evaluation of anti-glioma effect. In conclusion, the experimental data in vitro and in vivo indicated that the Tf/TAT-lip was a promising brain drug delivery system due to its high delivery efficiency across the BBB." @default.
• W367035320 created "2016-06-24" @default.
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• W367035320 date "2015-01-01" @default.
• W367035320 modified "2023-09-23" @default.
• W367035320 title "Transferrin and cell-penetrating peptide dual-functioned liposome for targeted drug delivery to glioma." @default.
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• W367035320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4402741" @default.
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