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- W3670701 abstract "Publisher Summary This chapter discusses the inhibition of viral neuraminidase as a new approach to the prevention of influenza. The usual objective of viral chemotherapy or immunoprophylaxis is the complete inhibition or restriction of infection. Another stratagem that has received insufficient attention is to achieve a lesser victory through a quantitative and partial limitation of infection sufficient to prevent disease but insufficient to inhibit the desirable immunizing effects of that infection. The chapter summarizes the basic approaches available for antiviral prophylaxis. In diseases with long incubation periods, such as rabies or even measles, administration of neutralizing antibody after infection can prevent or modify the evolution of disease. It is conceivable that sharp inhibition of viral replication by chemotherapy after the initiation of disease can have a similar effect. Another virtually untried approach is to immunize with minor antigenic components of the virus or to inhibit viral biological activities that are not essential for initiation of infection." @default.
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- W3670701 date "1975-01-01" @default.
- W3670701 modified "2023-09-27" @default.
- W3670701 title "Inhibition of Viral Neuraminidase As a New Approach to the Prevention of Influenza* *This work was monitored by the Commission on influenza of the Armed Forces Epidemiological Board, and was supported (in part) by the U. S. Army Medical Research and Development Command under research contract No. DADA1769-C-9137, by Public Health Service research grant No. AI09304 from the National Institute of Allergy and Infectious Diseases, and by contract No. U-2076 from the Health Research Council of the …" @default.
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- W3670701 doi "https://doi.org/10.1016/b978-0-12-560565-6.50014-0" @default.
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