Matches in SemOpenAlex for { <https://semopenalex.org/work/W36753352> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W36753352 endingPage "59" @default.
- W36753352 startingPage "49" @default.
- W36753352 abstract "Fast melt tablets, also known as fast dissolving tablets, disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate fast melt tablets of nimesulide by using Ocimum Sanctum seeds as a natural tablet superdisintegrant.Powdered Ocimum seeds were characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, loss on drying and microbial load. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in vitro and in vivo disintegration time, in-vitro dissolution and stability studies.The swelling index was evaluated to be 1600. An appreciable effect of the natural material was seen on tablet hardness and friability. The water absorption ratio increased from 56.15 +/- 0.85 to 80.76 +/- 0.70 (A1-A4). Water uptake coupled natural polymer swelling could be the most probable mechanism for concentration dependent reduction in disintegration time by the Ocimum Sanctum seeds. Porosity of the formulated tablets was found to increase from batch A1-A4. The in vitro disintegration results were in line with in vivo disintegration results. The f2 values (in comparison with Nimulid MD) of 95.90 and 93.65 were obtained with A3 and A4 batches respectively.It could be concluded that Ocimum Sanctum seeds could be used as a natural superdisintegrant in the formulation of fast melt tablets." @default.
- W36753352 created "2016-06-24" @default.
- W36753352 creator A5012670364 @default.
- W36753352 creator A5017672623 @default.
- W36753352 creator A5064177460 @default.
- W36753352 date "2012-01-01" @default.
- W36753352 modified "2023-09-25" @default.
- W36753352 title "Ocimum Sanctum seeds, a natural superdisintegrant: formulation and evaluation of fast melt tablets of nimesulide." @default.
- W36753352 cites W2006226699 @default.
- W36753352 cites W2035500125 @default.
- W36753352 cites W2047846970 @default.
- W36753352 cites W2075681156 @default.
- W36753352 cites W2093517267 @default.
- W36753352 cites W2106563238 @default.
- W36753352 cites W2108274215 @default.
- W36753352 cites W2121254975 @default.
- W36753352 cites W2138587373 @default.
- W36753352 cites W54444533 @default.
- W36753352 cites W8822932 @default.
- W36753352 cites W2187407178 @default.
- W36753352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22783733" @default.
- W36753352 hasPublicationYear "2012" @default.
- W36753352 type Work @default.
- W36753352 sameAs 36753352 @default.
- W36753352 citedByCount "9" @default.
- W36753352 countsByYear W367533522013 @default.
- W36753352 countsByYear W367533522014 @default.
- W36753352 countsByYear W367533522015 @default.
- W36753352 countsByYear W367533522016 @default.
- W36753352 countsByYear W367533522021 @default.
- W36753352 crossrefType "journal-article" @default.
- W36753352 hasAuthorship W36753352A5012670364 @default.
- W36753352 hasAuthorship W36753352A5017672623 @default.
- W36753352 hasAuthorship W36753352A5064177460 @default.
- W36753352 hasConcept C151995515 @default.
- W36753352 hasConcept C159985019 @default.
- W36753352 hasConcept C168314062 @default.
- W36753352 hasConcept C178790620 @default.
- W36753352 hasConcept C185592680 @default.
- W36753352 hasConcept C191168616 @default.
- W36753352 hasConcept C192562407 @default.
- W36753352 hasConcept C2776035855 @default.
- W36753352 hasConcept C2778540859 @default.
- W36753352 hasConcept C2779342943 @default.
- W36753352 hasConcept C2780658084 @default.
- W36753352 hasConcept C43617362 @default.
- W36753352 hasConcept C521977710 @default.
- W36753352 hasConcept C59822182 @default.
- W36753352 hasConcept C6648577 @default.
- W36753352 hasConcept C86803240 @default.
- W36753352 hasConcept C88380143 @default.
- W36753352 hasConcept C88463166 @default.
- W36753352 hasConceptScore W36753352C151995515 @default.
- W36753352 hasConceptScore W36753352C159985019 @default.
- W36753352 hasConceptScore W36753352C168314062 @default.
- W36753352 hasConceptScore W36753352C178790620 @default.
- W36753352 hasConceptScore W36753352C185592680 @default.
- W36753352 hasConceptScore W36753352C191168616 @default.
- W36753352 hasConceptScore W36753352C192562407 @default.
- W36753352 hasConceptScore W36753352C2776035855 @default.
- W36753352 hasConceptScore W36753352C2778540859 @default.
- W36753352 hasConceptScore W36753352C2779342943 @default.
- W36753352 hasConceptScore W36753352C2780658084 @default.
- W36753352 hasConceptScore W36753352C43617362 @default.
- W36753352 hasConceptScore W36753352C521977710 @default.
- W36753352 hasConceptScore W36753352C59822182 @default.
- W36753352 hasConceptScore W36753352C6648577 @default.
- W36753352 hasConceptScore W36753352C86803240 @default.
- W36753352 hasConceptScore W36753352C88380143 @default.
- W36753352 hasConceptScore W36753352C88463166 @default.
- W36753352 hasIssue "1" @default.
- W36753352 hasLocation W367533521 @default.
- W36753352 hasOpenAccess W36753352 @default.
- W36753352 hasPrimaryLocation W367533521 @default.
- W36753352 hasRelatedWork W1494703834 @default.
- W36753352 hasRelatedWork W1738910442 @default.
- W36753352 hasRelatedWork W2121254975 @default.
- W36753352 hasRelatedWork W2187690618 @default.
- W36753352 hasRelatedWork W2901746242 @default.
- W36753352 hasRelatedWork W3166358178 @default.
- W36753352 hasRelatedWork W36753352 @default.
- W36753352 hasRelatedWork W4220767912 @default.
- W36753352 hasRelatedWork W810131684 @default.
- W36753352 hasRelatedWork W2336574630 @default.
- W36753352 hasVolume "42" @default.
- W36753352 isParatext "false" @default.
- W36753352 isRetracted "false" @default.
- W36753352 magId "36753352" @default.
- W36753352 workType "article" @default.