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- W36791285 abstract "Three new agents are currently undergoing clinical trials: anistreplase, intravenous urokinase, and prourokinase. Anistreplase (APSAC) is a complex of anisoylated lys-plasminogen and streptokinase which is injected in a dose of 30 U over 2–5 min. Reperfusion rates of 60+10% and patency rates of 70–75% have been observed when it is given in <4 h. Mortality was reduced 48% after anistreplase in one study (AIMS). Intravenous urokinase has yielded reperfusion or patency rates of 60–70% in limited trial experience, with equivalent effects of TPA in one trial (GAUS). Current usage includes a loading injection (eg, 1.5 million U) followed by a maintenance infusion (eg, 1.5 million U/60–90 min). Combinations of urokinase and TPA are also undergoing testing. Prourokinase is a fibrin-selective precursor form of urokinase undergoing initial trials both as a single agent and in combinations with urokinase and TPA. These agents expand the spectrum of thrombolytic options and may begin to impact clinical therapy in the near future." @default.
- W36791285 created "2016-06-24" @default.
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- W36791285 date "1989-01-01" @default.
- W36791285 modified "2023-09-25" @default.
- W36791285 title "New Agents and New Insights for Thrombolytic Therapy in Acute Myocardial Infarction: Focus on Anistreplase, Urokinase, and Prourokinase" @default.
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- W36791285 doi "https://doi.org/10.1007/978-1-4613-1605-3_4" @default.
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