Matches in SemOpenAlex for { <https://semopenalex.org/work/W36792862> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W36792862 abstract "Colorectal cancer (CRC), a leading cause of cancer deaths, is characterised by two early molecular events: the expression of cyclo-oxygenease-2 (COX-2) and aberrant Wnt signalling. Culinary spices and their constituent polyphenols have been shown to inhibit both COX-2 expression and cancer cell growth in vitro. However, there is relatively little data on the effect of culinary spices on CRC cells. Thus, the aim of this study was two-fold: to investigate the impact of a selection of commonly used culinary spices (cinnamon, clove, ginger, nutmeg and turmeric) on the growth of CRC cell lines HCT116 (a COX-2 negative cell line) and HT29 (a COX-2 positive cell line); and to identify whether the measured inhibition is underpinned by their effect on s-catenin (a central signal transducer of the Wnt pathway and a marker of uncontrolled proliferation) and/or COX-2. Growth . inhibition studies indicated that all the spices tested were able to inhibit CRC cell proliferation in vitro and that their potency was influenced by the extraction solvent used and the cell line; the 50% inhibitory concentration (ICso) ranged from 3.5 gallic acid equivalents (GAE) Ilg/ml (clove) to 18.4 GAE Ilg/ml (cinnamon). Analysis of the data indicated that the amount of actual ground spice needed to achieve the ICso, for aqueous extracts only, did not exceed the amounts used in the preparation of food. Immunoblot analysis indicated that the spice extracts (SEs) did not have an effect on Wnt signalling via s-catenin and their impact on COX-2 could not be determined. In conclusion, this study shows that whole spice extracts inhibited the growth of colorectal cancer cells in vitro at quantities that can be achieved in the diet, and can thus be considered as promising dietary chern 0- preventative agents. However, further experiments are required for the elucidation of their mode of action. Interactions that occur between the constituent polyphenols of these spices may provide further insight into their chemo-preventative properties and also the chemo-therapeutic potential of their constituents." @default.
- W36792862 created "2016-06-24" @default.
- W36792862 creator A5034399497 @default.
- W36792862 date "2012-11-01" @default.
- W36792862 modified "2023-09-27" @default.
- W36792862 title "Inhibition of colorectal cancer cells 'in vitro': an investigation of the chemo-preventative action of common culinary spices" @default.
- W36792862 hasPublicationYear "2012" @default.
- W36792862 type Work @default.
- W36792862 sameAs 36792862 @default.
- W36792862 citedByCount "0" @default.
- W36792862 crossrefType "dissertation" @default.
- W36792862 hasAuthorship W36792862A5034399497 @default.
- W36792862 hasConcept C121608353 @default.
- W36792862 hasConcept C126322002 @default.
- W36792862 hasConcept C137620995 @default.
- W36792862 hasConcept C185592680 @default.
- W36792862 hasConcept C190283241 @default.
- W36792862 hasConcept C202751555 @default.
- W36792862 hasConcept C2777752497 @default.
- W36792862 hasConcept C2778004101 @default.
- W36792862 hasConcept C2778362808 @default.
- W36792862 hasConcept C2779707156 @default.
- W36792862 hasConcept C31573885 @default.
- W36792862 hasConcept C526805850 @default.
- W36792862 hasConcept C54355233 @default.
- W36792862 hasConcept C55493867 @default.
- W36792862 hasConcept C556039675 @default.
- W36792862 hasConcept C62112901 @default.
- W36792862 hasConcept C62478195 @default.
- W36792862 hasConcept C71924100 @default.
- W36792862 hasConcept C81885089 @default.
- W36792862 hasConcept C86803240 @default.
- W36792862 hasConcept C98274493 @default.
- W36792862 hasConceptScore W36792862C121608353 @default.
- W36792862 hasConceptScore W36792862C126322002 @default.
- W36792862 hasConceptScore W36792862C137620995 @default.
- W36792862 hasConceptScore W36792862C185592680 @default.
- W36792862 hasConceptScore W36792862C190283241 @default.
- W36792862 hasConceptScore W36792862C202751555 @default.
- W36792862 hasConceptScore W36792862C2777752497 @default.
- W36792862 hasConceptScore W36792862C2778004101 @default.
- W36792862 hasConceptScore W36792862C2778362808 @default.
- W36792862 hasConceptScore W36792862C2779707156 @default.
- W36792862 hasConceptScore W36792862C31573885 @default.
- W36792862 hasConceptScore W36792862C526805850 @default.
- W36792862 hasConceptScore W36792862C54355233 @default.
- W36792862 hasConceptScore W36792862C55493867 @default.
- W36792862 hasConceptScore W36792862C556039675 @default.
- W36792862 hasConceptScore W36792862C62112901 @default.
- W36792862 hasConceptScore W36792862C62478195 @default.
- W36792862 hasConceptScore W36792862C71924100 @default.
- W36792862 hasConceptScore W36792862C81885089 @default.
- W36792862 hasConceptScore W36792862C86803240 @default.
- W36792862 hasConceptScore W36792862C98274493 @default.
- W36792862 hasLocation W367928621 @default.
- W36792862 hasOpenAccess W36792862 @default.
- W36792862 hasPrimaryLocation W367928621 @default.
- W36792862 hasRelatedWork W2012790773 @default.
- W36792862 hasRelatedWork W2057985642 @default.
- W36792862 hasRelatedWork W2093564845 @default.
- W36792862 hasRelatedWork W2142835401 @default.
- W36792862 hasRelatedWork W2554188318 @default.
- W36792862 hasRelatedWork W2597285193 @default.
- W36792862 hasRelatedWork W2741562284 @default.
- W36792862 hasRelatedWork W2810503128 @default.
- W36792862 hasRelatedWork W2921236189 @default.
- W36792862 hasRelatedWork W2938720768 @default.
- W36792862 hasRelatedWork W2958544001 @default.
- W36792862 hasRelatedWork W3010139161 @default.
- W36792862 hasRelatedWork W3080940618 @default.
- W36792862 hasRelatedWork W3173861044 @default.
- W36792862 hasRelatedWork W3182982765 @default.
- W36792862 hasRelatedWork W3187305319 @default.
- W36792862 hasRelatedWork W3188258426 @default.
- W36792862 hasRelatedWork W3197436378 @default.
- W36792862 hasRelatedWork W577531881 @default.
- W36792862 hasRelatedWork W2736327774 @default.
- W36792862 isParatext "false" @default.
- W36792862 isRetracted "false" @default.
- W36792862 magId "36792862" @default.
- W36792862 workType "dissertation" @default.