Matches in SemOpenAlex for { <https://semopenalex.org/work/W36834675> ?p ?o ?g. }
- W36834675 endingPage "591" @default.
- W36834675 startingPage "586" @default.
- W36834675 abstract "Abstract Alexander Gutman was a pioneer in measuring total iodine and L-thyroxine (T 4 ) concentrations within the thyroid gland nearly 50 years ago. On this foundation, new analytical technics developed in the intervening years greatly expanded knowledge of intrathyroid hormone content. This review examines how the latter has contributed to the understanding of the physiology and physiopathology of specific problems currently of great Interest in thyroid research; namely, the source of circulating triiodothyronine (T 3 ) in normal man and the course of a newly described clinical entity, T 3 -toxicosis. The recent conclusive demonstration of the peripheral conversion of T 4 to T 3 in man raises the question of the proportion of total T 3 production normally derived from this pathway, as opposed to direct thyroid secretion. Direct analyses of T 4 to T 3 ratios in human thyroid tissue suggest that relatively little T 3 is derived directly from the thyroid; however, the inhomogeneity of intrathyroidal iodine pools, and the possibility that T 4 may be converted to T 3 within the thyroid, make this approach of limited value. The problem will be settled only by careful kinetic analyses making possible a comparison between the total T 3 production rate and that derived from peripheral T 4 deiodination. T 3 toxicosis is a recently described entity in which hyperthyroidism is associated with an increased serum T 3 concentration, together with a normal or decreased concentration of T 4 . In the usual form of thyrotoxicosis, in which both T 4 and T 3 levels are elevated, the thyroid also secretes disproportionately large quantities of T 3 relative to T 4 . Since there is evidence in animals and man that iodine deficiency favors synthesis and secretion of T 3 relative to T 4 , the relative-hypersecretion of T 3 in both varieties of thyrotoxicosis may reflect a relative intrathyroid iodine deficiency. That this possibility is more than speculative is suggested by Gutman's early finding of a decrease in the total iodine and T 4 content of thyrotoxic glands. The mechanism whereby intrathyroid iodine depletion may occur in the thyrotoxic gland remains obscure, however." @default.
- W36834675 created "2016-06-24" @default.
- W36834675 creator A5055826150 @default.
- W36834675 creator A5091065594 @default.
- W36834675 date "1974-05-01" @default.
- W36834675 modified "2023-09-27" @default.
- W36834675 title "Production of triiodothyronine in normal human subjects and in patients with hyperthyroidism" @default.
- W36834675 cites W1561478734 @default.
- W36834675 cites W1898716263 @default.
- W36834675 cites W1967272642 @default.
- W36834675 cites W1970716733 @default.
- W36834675 cites W1970871311 @default.
- W36834675 cites W1977492795 @default.
- W36834675 cites W1982432982 @default.
- W36834675 cites W1987923348 @default.
- W36834675 cites W1990550978 @default.
- W36834675 cites W1993799007 @default.
- W36834675 cites W2001793180 @default.
- W36834675 cites W2004192002 @default.
- W36834675 cites W2004482961 @default.
- W36834675 cites W2006457802 @default.
- W36834675 cites W2007535287 @default.
- W36834675 cites W2008618455 @default.
- W36834675 cites W2011154416 @default.
- W36834675 cites W2016009447 @default.
- W36834675 cites W2021267809 @default.
- W36834675 cites W2022350011 @default.
- W36834675 cites W2023307232 @default.
- W36834675 cites W2028302109 @default.
- W36834675 cites W2028498110 @default.
- W36834675 cites W2028691157 @default.
- W36834675 cites W2031451843 @default.
- W36834675 cites W2036376491 @default.
- W36834675 cites W2036983669 @default.
- W36834675 cites W2041160265 @default.
- W36834675 cites W2042157916 @default.
- W36834675 cites W2048193307 @default.
- W36834675 cites W2056664245 @default.
- W36834675 cites W2057132669 @default.
- W36834675 cites W2057720330 @default.
- W36834675 cites W2058689383 @default.
- W36834675 cites W2059010991 @default.
- W36834675 cites W2059868242 @default.
- W36834675 cites W2060432734 @default.
- W36834675 cites W2061619913 @default.
- W36834675 cites W2062743262 @default.
- W36834675 cites W2063152601 @default.
- W36834675 cites W2068331943 @default.
- W36834675 cites W2068394614 @default.
- W36834675 cites W2074226912 @default.
- W36834675 cites W2076203475 @default.
- W36834675 cites W2080806531 @default.
- W36834675 cites W2083856610 @default.
- W36834675 cites W2085707886 @default.
- W36834675 cites W2088575802 @default.
- W36834675 cites W2089639161 @default.
- W36834675 cites W2095811126 @default.
- W36834675 cites W2110401354 @default.
- W36834675 cites W2135957727 @default.
- W36834675 cites W2136980951 @default.
- W36834675 cites W2140243011 @default.
- W36834675 cites W2146072126 @default.
- W36834675 cites W2147206915 @default.
- W36834675 cites W2160583708 @default.
- W36834675 cites W2162840506 @default.
- W36834675 cites W2165111821 @default.
- W36834675 cites W281997436 @default.
- W36834675 cites W4233507701 @default.
- W36834675 cites W958795171 @default.
- W36834675 doi "https://doi.org/10.1016/0002-9343(74)90628-7" @default.
- W36834675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4604964" @default.
- W36834675 hasPublicationYear "1974" @default.
- W36834675 type Work @default.
- W36834675 sameAs 36834675 @default.
- W36834675 citedByCount "14" @default.
- W36834675 countsByYear W368346752013 @default.
- W36834675 crossrefType "journal-article" @default.
- W36834675 hasAuthorship W36834675A5055826150 @default.
- W36834675 hasAuthorship W36834675A5091065594 @default.
- W36834675 hasConcept C126322002 @default.
- W36834675 hasConcept C134018914 @default.
- W36834675 hasConcept C2778288131 @default.
- W36834675 hasConcept C526584372 @default.
- W36834675 hasConcept C71924100 @default.
- W36834675 hasConceptScore W36834675C126322002 @default.
- W36834675 hasConceptScore W36834675C134018914 @default.
- W36834675 hasConceptScore W36834675C2778288131 @default.
- W36834675 hasConceptScore W36834675C526584372 @default.
- W36834675 hasConceptScore W36834675C71924100 @default.
- W36834675 hasIssue "5" @default.
- W36834675 hasLocation W368346751 @default.
- W36834675 hasLocation W368346752 @default.
- W36834675 hasOpenAccess W36834675 @default.
- W36834675 hasPrimaryLocation W368346751 @default.
- W36834675 hasRelatedWork W1963172981 @default.
- W36834675 hasRelatedWork W1966695668 @default.
- W36834675 hasRelatedWork W1976563906 @default.
- W36834675 hasRelatedWork W2037952323 @default.