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• W36834675 abstract "Abstract Alexander Gutman was a pioneer in measuring total iodine and L-thyroxine (T 4 ) concentrations within the thyroid gland nearly 50 years ago. On this foundation, new analytical technics developed in the intervening years greatly expanded knowledge of intrathyroid hormone content. This review examines how the latter has contributed to the understanding of the physiology and physiopathology of specific problems currently of great Interest in thyroid research; namely, the source of circulating triiodothyronine (T 3 ) in normal man and the course of a newly described clinical entity, T 3 -toxicosis. The recent conclusive demonstration of the peripheral conversion of T 4 to T 3 in man raises the question of the proportion of total T 3 production normally derived from this pathway, as opposed to direct thyroid secretion. Direct analyses of T 4 to T 3 ratios in human thyroid tissue suggest that relatively little T 3 is derived directly from the thyroid; however, the inhomogeneity of intrathyroidal iodine pools, and the possibility that T 4 may be converted to T 3 within the thyroid, make this approach of limited value. The problem will be settled only by careful kinetic analyses making possible a comparison between the total T 3 production rate and that derived from peripheral T 4 deiodination. T 3 toxicosis is a recently described entity in which hyperthyroidism is associated with an increased serum T 3 concentration, together with a normal or decreased concentration of T 4 . In the usual form of thyrotoxicosis, in which both T 4 and T 3 levels are elevated, the thyroid also secretes disproportionately large quantities of T 3 relative to T 4 . Since there is evidence in animals and man that iodine deficiency favors synthesis and secretion of T 3 relative to T 4 , the relative-hypersecretion of T 3 in both varieties of thyrotoxicosis may reflect a relative intrathyroid iodine deficiency. That this possibility is more than speculative is suggested by Gutman's early finding of a decrease in the total iodine and T 4 content of thyrotoxic glands. The mechanism whereby intrathyroid iodine depletion may occur in the thyrotoxic gland remains obscure, however." @default.
• W36834675 created "2016-06-24" @default.
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• W36834675 date "1974-05-01" @default.
• W36834675 modified "2023-09-27" @default.
• W36834675 title "Production of triiodothyronine in normal human subjects and in patients with hyperthyroidism" @default.
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• W36834675 doi "https://doi.org/10.1016/0002-9343(74)90628-7" @default.
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