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- W36839778 abstract "A nursing mother with ulcerative colitis was treated with salicylazosulfapyridine (SASP, Azulfidine). Multiple milk samples werc collectcd over a 2-month period. Maternal plasma, saliva, urine and the nursing infant's urine were collected. All fluids were analyzed for SASP and its metabolites. Milk did not contain SASP or its 5-amino salicylate componcnt. Sulfapyridine (SPJ and its metabolites were present in milk; the SP level was fairly constant at 3-6 μg/ml. The milk/saliva ratio for SP was 0.81; the milk/plasma ratio for SP was 0.60 and 0.63. Assuming an average milk concentration of 5 μg/ml of SP, the estimated 24-hour secretion (800 cm 3 milk) would be approximately 4 mg or 0.3% of maternal dosc of SP in the form of SASP. The levels of SP and metabolites determined in random urine samples from the infant were 3-4 μg/ml or a 24-hour excretion of 1.2-1.6 mg (30-40% of the total dose in milk). This exposure did not seem hazardous to this infant." @default.
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- W36839778 date "1980-01-01" @default.
- W36839778 modified "2023-09-27" @default.
- W36839778 title "Disposition of Salicylazosulfapyridine ( Azulfidine) and Metabolites in Human Breast Milk" @default.
- W36839778 doi "https://doi.org/10.1159/000455519" @default.
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