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• W368465775 abstract "The hot pepper, or more precicely capsaicin, the hot component of chilli peppers of the Capsicum family, was the key that opened new horizons in the field of analgesics and the pharmacology of nociceptors. It is surprising that during the last century real breakthroughs in drug development in the field of analgesics were not achieved. Remarkably, medical doctors at the end of the 19th century used analgesics that act on opioid receptors and cyclooxygenase (COX) enzymes, just as contemporary physicians do. Until quite recently, no chapters on drugs acting on nociceptive sensory neurons could be found in modern pharmacology textbooks, in striking contrast to several chapters on the sympathetic or parasympathetic nervous system, for which a continuously growing number of drug targets has been revealed. The roots of this flourishing pharmacology of the autonomic nervous system can be traced back to the analysis of the mode of action of naturally occurring drugs such as nicotine (Langley and Dickinson, 18891), ergotoxine (Dale, 19062) and atropine (Loewi, 19213). These brilliant studies on alkaloids provided the first evidence for the very existence of mediators of neurohumoral transmission and raised clues for drug development (for references, see [1]). An experimental study by Andreas Hőgyes [2], published during this pioneering period of pharmacology, was the first attempt to describe the actions of capsaicin under experimental conditions. These observations led Hőgyes to conclude that this compound acts mainly on sensory nerves (‘Capsicol hauptsachlich auf die sensiblen Nerven wirkte’). In traditional treatments of arthritic diseases, capsaicin was applied topically as a ‘counterirritant’, but its pharmacology remained neglected for seven decades [3, 4]." @default.
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• W368465775 date "2005-01-01" @default.
• W368465775 modified "2023-09-27" @default.
• W368465775 title "Hot peppers, pain and analgesics" @default.
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• W368465775 doi "https://doi.org/10.1007/3-7643-7379-2_1" @default.
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