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• W368840492 abstract "Primarily defined by their antigen presenting function, dendritic cells (DC) are equipped with the unique ability to initiate and regulate immune responses. A less conventional characteristic of DC has been highlighted more recently: their capability to directly kill tumor cells when appropriately activated. The main objectives of the study presented herein were to analyze the molecular regulation of DC cytotoxic activity and to determine how the tumoricidal potential of DC may influence their cardinal antigen presenting function. To address these questions, DC were generated from myeloid precursors with either IL-4 (IL-4 DC) or IL-15 (IL-15 DC). We demonstrate that IL-4 and IL-15 DC exhibit similar iNOS-dependent tumor killing activity when activated with the toll-like receptor (TLR)-4 agonist LPS. However, stimulation with interferon (IFN)-γ selectively induces iNOS-dependent cytotoxic activity of IL-4 but not IL-15 DC. Possible differences in the signaling pathways controlling iNOS expression in these two DC populations were then examined. In both IL-4 and IL-15 DC, LPS initially activates NF-κB, followed by secondary activation of components of the ISGF3 transcription factor. Using inhibitors and knockout mice we established that disruption of the NF-κB or ISGF3 signaling axes impaired LPS-induced iNOS expression in IL-15 DC with little to no effect in IL-4 DC. A distinct and separate JAK-STAT pathway is required for iNOS induction in IL-4 DC activated with IFN-γ. IL-15 DC express high levels of PIAS1 and phosphorylated STAT-3 which act as independent inhibitors of iNOS expression upon stimulation with IFN-γ. Inhibiting PIAS1 with silencing RNA (siRNA) along with STAT-3 inhibition or knockdown restores iNOS expression and the tumor" @default.
• W368840492 created "2016-06-24" @default.
• W368840492 creator A5010807859 @default.
• W368840492 date "2012-01-01" @default.
• W368840492 modified "2023-09-22" @default.
• W368840492 title "MOLECULAR REGULATION OF THE TUMOR KILLING ACTIVITY OF DENDRITIC CELLS" @default.
• W368840492 cites W1483194800 @default.
• W368840492 cites W148604462 @default.
• W368840492 cites W1490684766 @default.
• W368840492 cites W1503844766 @default.
• W368840492 cites W1503899313 @default.
• W368840492 cites W1508383316 @default.
• W368840492 cites W1517875520 @default.
• W368840492 cites W1529459648 @default.
• W368840492 cites W1530044612 @default.
• W368840492 cites W1530235393 @default.
• W368840492 cites W1531093118 @default.
• W368840492 cites W1540455628 @default.
• W368840492 cites W1544965678 @default.
• W368840492 cites W1561591381 @default.
• W368840492 cites W1565046500 @default.
• W368840492 cites W1570748289 @default.
• W368840492 cites W1573363574 @default.
• W368840492 cites W1578257252 @default.
• W368840492 cites W1582077486 @default.
• W368840492 cites W1585754595 @default.
• W368840492 cites W1591881963 @default.
• W368840492 cites W1598843567 @default.
• W368840492 cites W1600231838 @default.
• W368840492 cites W1619959770 @default.
• W368840492 cites W1622259963 @default.
• W368840492 cites W1625919546 @default.
• W368840492 cites W1642873092 @default.
• W368840492 cites W1658445661 @default.
• W368840492 cites W1661544713 @default.
• W368840492 cites W1661698621 @default.
• W368840492 cites W1663861494 @default.
• W368840492 cites W1671448076 @default.
• W368840492 cites W1671935408 @default.
• W368840492 cites W1678477267 @default.
• W368840492 cites W1761055895 @default.
• W368840492 cites W1793379874 @default.
• W368840492 cites W1800111497 @default.
• W368840492 cites W1864835919 @default.
• W368840492 cites W1867019379 @default.
• W368840492 cites W1867960490 @default.
• W368840492 cites W1876464564 @default.
• W368840492 cites W1877245175 @default.
• W368840492 cites W1884519552 @default.
• W368840492 cites W1898102248 @default.
• W368840492 cites W1904840222 @default.
• W368840492 cites W1914229355 @default.
• W368840492 cites W1919712230 @default.
• W368840492 cites W1925817305 @default.
• W368840492 cites W1931280869 @default.
• W368840492 cites W1947771442 @default.
• W368840492 cites W1957245242 @default.
• W368840492 cites W1964151408 @default.
• W368840492 cites W1964586588 @default.
• W368840492 cites W1966553244 @default.
• W368840492 cites W1966916002 @default.
• W368840492 cites W1967229707 @default.
• W368840492 cites W1967404929 @default.
• W368840492 cites W1968459329 @default.
• W368840492 cites W1968783338 @default.
• W368840492 cites W1968950760 @default.
• W368840492 cites W1969534996 @default.
• W368840492 cites W1970177550 @default.
• W368840492 cites W1970925130 @default.
• W368840492 cites W1971595657 @default.
• W368840492 cites W1973251492 @default.
• W368840492 cites W1973389945 @default.
• W368840492 cites W1975778511 @default.
• W368840492 cites W1976899534 @default.
• W368840492 cites W1977080220 @default.
• W368840492 cites W1977179270 @default.
• W368840492 cites W1977665068 @default.
• W368840492 cites W1978942158 @default.
• W368840492 cites W1979014817 @default.
• W368840492 cites W1980445246 @default.
• W368840492 cites W1980690619 @default.
• W368840492 cites W1981070621 @default.
• W368840492 cites W1981248896 @default.
• W368840492 cites W1981787863 @default.
• W368840492 cites W1982951034 @default.
• W368840492 cites W1983268059 @default.
• W368840492 cites W1983306083 @default.
• W368840492 cites W1983365509 @default.
• W368840492 cites W1983412131 @default.
• W368840492 cites W1983467202 @default.
• W368840492 cites W1985040895 @default.
• W368840492 cites W1985444402 @default.
• W368840492 cites W1985804036 @default.
• W368840492 cites W1987589866 @default.
• W368840492 cites W1987591286 @default.
• W368840492 cites W1988924112 @default.
• W368840492 cites W1989514486 @default.
• W368840492 cites W1990083653 @default.
• W368840492 cites W1991601985 @default.
• W368840492 cites W1992265680 @default.

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