Matches in SemOpenAlex for { <https://semopenalex.org/work/W36896502> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W36896502 endingPage "13" @default.
- W36896502 startingPage "508" @default.
- W36896502 abstract "A variety of T-cell parameters have been analysed in two H-2 compatible strains of mice, B10.BR and BALB/K, which differ in an absolute fashion in their ability to resist infection with the parasitic nematode Trichuris muris: BALB/K mice expel T. muris relatively rapidly, whereas B10.BR mice are unable to expel the parasite before the infection reaches patency. Analysis of Th1- and Th2-specific cytokines (IFN-gamma and IL-5, respectively) produced by in vitro Con A-stimulated mesenteric lymph node cells (MLNC) from infected and normal mice demonstrated that MLNC from resistant BALB/K mice produced high levels of IL-5 and low levels of IFN-gamma whilst B10.BR MLNC secreted large amounts of IFN-gamma in the relative absence of IL-5. As an in vivo correlate of in vitro IL-5 production, peripheral and tissue eosinophilia were quantified during the course of infection in the two strains of mice. No peripheral eosinophilia was observed in BALB/K or B10.BR individuals. However, a considerable intestinal eosinophilia was seen in the high IL-5-producing BALB/K mice compared to normal levels. Differences observed in cytokine profiles were not due to differential changes in the numbers of T cells within the MLN. Indeed, FACS analysis revealed a decrease in the relative percentage of CD4+ and CD8+ T cells in both strains of mice post-infection. Our results suggest that resistance to T. muris involves the preferential induction of Th cells which secrete IL-5, whilst cells of a different Th subset (IFN-gamma producing) predominate in chronically infected mice. As such, this represents the first description of a correlation between the reciprocal activation of Th cell subsets in relation to acute or chronic intestinal infection with the same parasite in the same host species." @default.
- W36896502 created "2016-06-24" @default.
- W36896502 creator A5041111492 @default.
- W36896502 creator A5057653322 @default.
- W36896502 date "1991-04-01" @default.
- W36896502 modified "2023-10-18" @default.
- W36896502 title "Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection." @default.
- W36896502 cites W1495896580 @default.
- W36896502 cites W1542650808 @default.
- W36896502 cites W1546288178 @default.
- W36896502 cites W1570219583 @default.
- W36896502 cites W1621064629 @default.
- W36896502 cites W1800390635 @default.
- W36896502 cites W1899754071 @default.
- W36896502 cites W1942668068 @default.
- W36896502 cites W1964347128 @default.
- W36896502 cites W1975364461 @default.
- W36896502 cites W1990568245 @default.
- W36896502 cites W2000132584 @default.
- W36896502 cites W2005246059 @default.
- W36896502 cites W2034388078 @default.
- W36896502 cites W2041765961 @default.
- W36896502 cites W2065367149 @default.
- W36896502 cites W2069206672 @default.
- W36896502 cites W2080820892 @default.
- W36896502 cites W2116217588 @default.
- W36896502 cites W2118511255 @default.
- W36896502 cites W2127278205 @default.
- W36896502 cites W2142990698 @default.
- W36896502 cites W2163991393 @default.
- W36896502 cites W2169283009 @default.
- W36896502 cites W2318780101 @default.
- W36896502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384369" @default.
- W36896502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1903765" @default.
- W36896502 hasPublicationYear "1991" @default.
- W36896502 type Work @default.
- W36896502 sameAs 36896502 @default.
- W36896502 citedByCount "60" @default.
- W36896502 countsByYear W368965022014 @default.
- W36896502 countsByYear W368965022015 @default.
- W36896502 countsByYear W368965022017 @default.
- W36896502 countsByYear W368965022019 @default.
- W36896502 countsByYear W368965022022 @default.
- W36896502 countsByYear W368965022023 @default.
- W36896502 crossrefType "journal-article" @default.
- W36896502 hasAuthorship W36896502A5041111492 @default.
- W36896502 hasAuthorship W36896502A5057653322 @default.
- W36896502 hasConcept C150903083 @default.
- W36896502 hasConcept C167672396 @default.
- W36896502 hasConcept C202751555 @default.
- W36896502 hasConcept C203014093 @default.
- W36896502 hasConcept C207001950 @default.
- W36896502 hasConcept C2777129736 @default.
- W36896502 hasConcept C2778690821 @default.
- W36896502 hasConcept C55493867 @default.
- W36896502 hasConcept C86803240 @default.
- W36896502 hasConcept C8891405 @default.
- W36896502 hasConceptScore W36896502C150903083 @default.
- W36896502 hasConceptScore W36896502C167672396 @default.
- W36896502 hasConceptScore W36896502C202751555 @default.
- W36896502 hasConceptScore W36896502C203014093 @default.
- W36896502 hasConceptScore W36896502C207001950 @default.
- W36896502 hasConceptScore W36896502C2777129736 @default.
- W36896502 hasConceptScore W36896502C2778690821 @default.
- W36896502 hasConceptScore W36896502C55493867 @default.
- W36896502 hasConceptScore W36896502C86803240 @default.
- W36896502 hasConceptScore W36896502C8891405 @default.
- W36896502 hasIssue "4" @default.
- W36896502 hasLocation W368965021 @default.
- W36896502 hasOpenAccess W36896502 @default.
- W36896502 hasPrimaryLocation W368965021 @default.
- W36896502 hasRelatedWork W1552035119 @default.
- W36896502 hasRelatedWork W1993985418 @default.
- W36896502 hasRelatedWork W2047209980 @default.
- W36896502 hasRelatedWork W2056022494 @default.
- W36896502 hasRelatedWork W2086961098 @default.
- W36896502 hasRelatedWork W2150751062 @default.
- W36896502 hasRelatedWork W3044811073 @default.
- W36896502 hasRelatedWork W3214012263 @default.
- W36896502 hasRelatedWork W2185732136 @default.
- W36896502 hasRelatedWork W2396811992 @default.
- W36896502 hasVolume "72" @default.
- W36896502 isParatext "false" @default.
- W36896502 isRetracted "false" @default.
- W36896502 magId "36896502" @default.
- W36896502 workType "article" @default.