FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W369545030> ?p ?o ?g. }

• W369545030 endingPage "96" @default.
• W369545030 startingPage "87" @default.
• W369545030 abstract "Hydroxypropyl-β-cyclodextrin (HP-β-CD) is being explored as excipient for administration of poorly soluble NCE's in pediatrics. In support of pharmaceutical development, non-clinical studies were performed to investigate whether oral and intravenous administration of HP-β-CD showed a different response in juvenile rats versus adult rats. Juvenile rats received HP-β-CD via the intravenous route at dose levels of 50, 200 and 400mg/kg/day from postnatal day 16 to 44, or via oral gavage at 500, 1000 and 2000mg/kg/day from postnatal day 4 to 46. In addition to in vivo parameters, toxicokinetics and post-mortem evaluations were conducted. The main findings were related to the renal excretion of intact HP-β-CD and were regarded as non-adverse transient adaptive responses. The pathogenesis of the osmotic nephrosis-like changes are discussed. With increasing age a more effective renal clearance of HP-β-CD is present in line with the postnatal functional maturation of the kidney. In addition, following oral administration an increase in soft stools was seen which was related to osmotic water retention in the large intestine. The findings in the juvenile studies are very similar to those observed in previously performed adult rat studies at similar dose levels, same routes and similar or longer dose duration. No novel toxicity was seen in the juvenile studies." @default.
• W369545030 created "2016-06-24" @default.
• W369545030 creator A5003388574 @default.
• W369545030 creator A5013112545 @default.
• W369545030 creator A5016931412 @default.
• W369545030 creator A5022426595 @default.
• W369545030 creator A5033784932 @default.
• W369545030 creator A5067799700 @default.
• W369545030 date "2015-08-01" @default.
• W369545030 modified "2023-09-23" @default.
• W369545030 title "Juvenile animal testing of hydroxypropyl-β-cyclodextrin in support of pediatric drug development" @default.
• W369545030 cites W1564294920 @default.
• W369545030 cites W1586403164 @default.
• W369545030 cites W1697337825 @default.
• W369545030 cites W1932268843 @default.
• W369545030 cites W1967244297 @default.
• W369545030 cites W1989863356 @default.
• W369545030 cites W2011172462 @default.
• W369545030 cites W2015191233 @default.
• W369545030 cites W2020520992 @default.
• W369545030 cites W2031292272 @default.
• W369545030 cites W2033144166 @default.
• W369545030 cites W2037526692 @default.
• W369545030 cites W2038009411 @default.
• W369545030 cites W2041441464 @default.
• W369545030 cites W2044609602 @default.
• W369545030 cites W2047123619 @default.
• W369545030 cites W2047806114 @default.
• W369545030 cites W2054800049 @default.
• W369545030 cites W2055091943 @default.
• W369545030 cites W2068397233 @default.
• W369545030 cites W2074582913 @default.
• W369545030 cites W2101916105 @default.
• W369545030 cites W2107001533 @default.
• W369545030 cites W2116421507 @default.
• W369545030 cites W2128597004 @default.
• W369545030 cites W2144417922 @default.
• W369545030 cites W2144555231 @default.
• W369545030 cites W2146942628 @default.
• W369545030 cites W2148512388 @default.
• W369545030 cites W2149679050 @default.
• W369545030 cites W4237777089 @default.
• W369545030 cites W4246407743 @default.
• W369545030 cites W4247852925 @default.
• W369545030 doi "https://doi.org/10.1016/j.reprotox.2015.05.010" @default.
• W369545030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26013174" @default.
• W369545030 hasPublicationYear "2015" @default.
• W369545030 type Work @default.
• W369545030 sameAs 369545030 @default.
• W369545030 citedByCount "8" @default.
• W369545030 countsByYear W3695450302018 @default.
• W369545030 countsByYear W3695450302019 @default.
• W369545030 countsByYear W3695450302020 @default.
• W369545030 countsByYear W3695450302021 @default.
• W369545030 countsByYear W3695450302022 @default.
• W369545030 crossrefType "journal-article" @default.
• W369545030 hasAuthorship W369545030A5003388574 @default.
• W369545030 hasAuthorship W369545030A5013112545 @default.
• W369545030 hasAuthorship W369545030A5016931412 @default.
• W369545030 hasAuthorship W369545030A5022426595 @default.
• W369545030 hasAuthorship W369545030A5033784932 @default.
• W369545030 hasAuthorship W369545030A5067799700 @default.
• W369545030 hasConcept C115961737 @default.
• W369545030 hasConcept C126322002 @default.
• W369545030 hasConcept C134018914 @default.
• W369545030 hasConcept C150903083 @default.
• W369545030 hasConcept C195289149 @default.
• W369545030 hasConcept C197934379 @default.
• W369545030 hasConcept C207001950 @default.
• W369545030 hasConcept C2776093070 @default.
• W369545030 hasConcept C2777056448 @default.
• W369545030 hasConcept C2780035454 @default.
• W369545030 hasConcept C29730261 @default.
• W369545030 hasConcept C42407357 @default.
• W369545030 hasConcept C54355233 @default.
• W369545030 hasConcept C71924100 @default.
• W369545030 hasConcept C86803240 @default.
• W369545030 hasConcept C98274493 @default.
• W369545030 hasConceptScore W369545030C115961737 @default.
• W369545030 hasConceptScore W369545030C126322002 @default.
• W369545030 hasConceptScore W369545030C134018914 @default.
• W369545030 hasConceptScore W369545030C150903083 @default.
• W369545030 hasConceptScore W369545030C195289149 @default.
• W369545030 hasConceptScore W369545030C197934379 @default.
• W369545030 hasConceptScore W369545030C207001950 @default.
• W369545030 hasConceptScore W369545030C2776093070 @default.
• W369545030 hasConceptScore W369545030C2777056448 @default.
• W369545030 hasConceptScore W369545030C2780035454 @default.
• W369545030 hasConceptScore W369545030C29730261 @default.
• W369545030 hasConceptScore W369545030C42407357 @default.
• W369545030 hasConceptScore W369545030C54355233 @default.
• W369545030 hasConceptScore W369545030C71924100 @default.
• W369545030 hasConceptScore W369545030C86803240 @default.
• W369545030 hasConceptScore W369545030C98274493 @default.
• W369545030 hasFunder F4320337415 @default.
• W369545030 hasLocation W3695450301 @default.
• W369545030 hasLocation W3695450302 @default.
• W369545030 hasOpenAccess W369545030 @default.

• next