FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W370538813> ?p ?o ?g. }

• W370538813 endingPage "e0124946" @default.
• W370538813 startingPage "e0124946" @default.
• W370538813 abstract "A number of naturally occurring mutations of human apolipoprotein A-I (apoA-I) have been associated with hereditary amyloidoses. The molecular mechanisms involved in amyloid-associated pathology remain largely unknown. Here we examined the effects of the Arg173Pro point mutation in apoA-I on the structure, stability, and aggregation propensity, as well as on the ability to bind to putative ligands. Our results indicate that the mutation induces a drastic loss of stability, and a lower efficiency to bind to phospholipid vesicles at physiological pH, which could determine the observed higher tendency to aggregate as pro-amyloidogenic complexes. Incubation under acidic conditions does not seem to induce significant desestabilization or aggregation tendency, neither does it contribute to the binding of the mutant to sodium dodecyl sulfate. While the binding to this detergent is higher for the mutant as compared to wt apoA-I, the interaction of the Arg173Pro variant with heparin depends on pH, being lower at pH 5.0 and higher than wt under physiological pH conditions. We suggest that binding to ligands as heparin or other glycosaminoglycans could be key events tuning the fine details of the interaction of apoA-I variants with the micro-environment, and probably eliciting the toxicity of these variants in hereditary amyloidoses." @default.
• W370538813 created "2016-06-24" @default.
• W370538813 creator A5009095648 @default.
• W370538813 creator A5010408234 @default.
• W370538813 creator A5019337302 @default.
• W370538813 creator A5027742992 @default.
• W370538813 creator A5030085667 @default.
• W370538813 creator A5048783571 @default.
• W370538813 creator A5070591317 @default.
• W370538813 date "2015-05-07" @default.
• W370538813 modified "2023-10-09" @default.
• W370538813 title "Amyloidogenic Propensity of a Natural Variant of Human Apolipoprotein A-I: Stability and Interaction with Ligands" @default.
• W370538813 cites W1588296570 @default.
• W370538813 cites W1842594908 @default.
• W370538813 cites W1966614683 @default.
• W370538813 cites W1970924050 @default.
• W370538813 cites W1971691411 @default.
• W370538813 cites W1979813728 @default.
• W370538813 cites W1985404425 @default.
• W370538813 cites W1985962986 @default.
• W370538813 cites W1989508919 @default.
• W370538813 cites W1990058313 @default.
• W370538813 cites W1996341064 @default.
• W370538813 cites W1997094739 @default.
• W370538813 cites W2006515971 @default.
• W370538813 cites W2007254026 @default.
• W370538813 cites W2008539555 @default.
• W370538813 cites W2010822282 @default.
• W370538813 cites W2012455318 @default.
• W370538813 cites W2014485936 @default.
• W370538813 cites W2015426525 @default.
• W370538813 cites W2028141811 @default.
• W370538813 cites W2041759991 @default.
• W370538813 cites W2043750940 @default.
• W370538813 cites W2051359509 @default.
• W370538813 cites W2053574637 @default.
• W370538813 cites W2059357684 @default.
• W370538813 cites W2063174765 @default.
• W370538813 cites W2065547357 @default.
• W370538813 cites W2067675815 @default.
• W370538813 cites W2074039087 @default.
• W370538813 cites W2085498526 @default.
• W370538813 cites W2090716049 @default.
• W370538813 cites W2092979390 @default.
• W370538813 cites W2094195129 @default.
• W370538813 cites W2098517342 @default.
• W370538813 cites W2108305553 @default.
• W370538813 cites W2110740104 @default.
• W370538813 cites W2112336169 @default.
• W370538813 cites W2114685914 @default.
• W370538813 cites W2122055094 @default.
• W370538813 cites W2124930217 @default.
• W370538813 cites W2128635872 @default.
• W370538813 cites W2135806933 @default.
• W370538813 cites W2141462626 @default.
• W370538813 cites W2144473676 @default.
• W370538813 cites W2155406689 @default.
• W370538813 cites W2332032243 @default.
• W370538813 cites W4243810799 @default.
• W370538813 cites W4293247451 @default.
• W370538813 doi "https://doi.org/10.1371/journal.pone.0124946" @default.
• W370538813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4423886" @default.
• W370538813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25950566" @default.
• W370538813 hasPublicationYear "2015" @default.
• W370538813 type Work @default.
• W370538813 sameAs 370538813 @default.
• W370538813 citedByCount "25" @default.
• W370538813 countsByYear W3705388132016 @default.
• W370538813 countsByYear W3705388132017 @default.
• W370538813 countsByYear W3705388132018 @default.
• W370538813 countsByYear W3705388132020 @default.
• W370538813 countsByYear W3705388132021 @default.
• W370538813 countsByYear W3705388132022 @default.
• W370538813 crossrefType "journal-article" @default.
• W370538813 hasAuthorship W370538813A5009095648 @default.
• W370538813 hasAuthorship W370538813A5010408234 @default.
• W370538813 hasAuthorship W370538813A5019337302 @default.
• W370538813 hasAuthorship W370538813A5027742992 @default.
• W370538813 hasAuthorship W370538813A5030085667 @default.
• W370538813 hasAuthorship W370538813A5048783571 @default.
• W370538813 hasAuthorship W370538813A5070591317 @default.
• W370538813 hasBestOaLocation W3705388131 @default.
• W370538813 hasConcept C104317684 @default.
• W370538813 hasConcept C12554922 @default.
• W370538813 hasConcept C136238340 @default.
• W370538813 hasConcept C143065580 @default.
• W370538813 hasConcept C176944494 @default.
• W370538813 hasConcept C179104552 @default.
• W370538813 hasConcept C185592680 @default.
• W370538813 hasConcept C2777557582 @default.
• W370538813 hasConcept C2777633098 @default.
• W370538813 hasConcept C2778163477 @default.
• W370538813 hasConcept C2778918659 @default.
• W370538813 hasConcept C41625074 @default.
• W370538813 hasConcept C501734568 @default.
• W370538813 hasConcept C51639874 @default.
• W370538813 hasConcept C55493867 @default.
• W370538813 hasConcept C62746215 @default.

• next