Matches in SemOpenAlex for { <https://semopenalex.org/work/W37070689> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W37070689 abstract "The analysis of cDNA clones for human (1,2) and rat (3) insulin-like growth factor-II (IGF-II)1 has led to the prediction that the processed forms of the growth factors, i.e. Mr = 7422 (67 amino acids) for human IGF-II are synthesized as precursors with an extension of 89 amino acids at the carboxyl terminus. This extension is termed the E domain. Moses et al (4) identified two precursor forms of rat IGF-II (originally designated multiplication-stimulating activity) in the conditioned medium of Buffalo rat liver, i.e. BRL-3A, cells with appMrs = 16,270 (MSA-1) and 8,700 (MSA-II). Human serum, spinal fluid and tissue extracts also contain high Mr forms of IGF-II (5-8). Zumstein et al., (5) have purified a Mr = 10,000 variant form of IGF-II from serum that contained Cys-Gly-Asp for Ser33 in the C domain and an E domain extension of 21- amino acids. This 10 kDa IGF-II may be similar or identical to the “big IGF-II” that was reported to be present in human serum and in spinal fluid (6). We have isolated a still larger form of IGF-II from normal human serum (7). N-terminal amino acid sequence analysis through the first 28 residues and RRAs using rat placental membranes established it as a form of IGF-II. As evidenced from its mobility during SDS-PAGE, it has an appMr = 15,000. Very recently, Hudgins et al., (8) established that normal human serum contains several forms of precursor IGF- II with acidic isoelectric points, i.e. pI’s. The mass and acidic nature of one of these molecules with an apparent Mr= 15,000 was contributed, in part, by polysaccharides and sialic acids, respectively (8). These results may explain the observations of several investigators that extracts from the tissues and serum of patients with malignant tumors contain a broad size range of IGF-II (2,9,10)." @default.
- W37070689 created "2016-06-24" @default.
- W37070689 creator A5018161686 @default.
- W37070689 creator A5024375229 @default.
- W37070689 creator A5042905374 @default.
- W37070689 creator A5066204364 @default.
- W37070689 creator A5075249830 @default.
- W37070689 creator A5086368387 @default.
- W37070689 date "1991-01-01" @default.
- W37070689 modified "2023-09-27" @default.
- W37070689 title "Development of a Specific Radioimmuno Assay for E Domain Containing Forms of Insulin-Like Growth Factor II" @default.
- W37070689 cites W1995970177 @default.
- W37070689 cites W1996031776 @default.
- W37070689 cites W2005578476 @default.
- W37070689 cites W2013493568 @default.
- W37070689 cites W2020702186 @default.
- W37070689 cites W2029503971 @default.
- W37070689 cites W2033785962 @default.
- W37070689 cites W2036961244 @default.
- W37070689 cites W2076857471 @default.
- W37070689 cites W2078680796 @default.
- W37070689 cites W2081075932 @default.
- W37070689 cites W2087496366 @default.
- W37070689 cites W2100837269 @default.
- W37070689 cites W2125632609 @default.
- W37070689 cites W2169916499 @default.
- W37070689 doi "https://doi.org/10.1007/978-1-4684-5949-4_5" @default.
- W37070689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1722622" @default.
- W37070689 hasPublicationYear "1991" @default.
- W37070689 type Work @default.
- W37070689 sameAs 37070689 @default.
- W37070689 citedByCount "11" @default.
- W37070689 crossrefType "book-chapter" @default.
- W37070689 hasAuthorship W37070689A5018161686 @default.
- W37070689 hasAuthorship W37070689A5024375229 @default.
- W37070689 hasAuthorship W37070689A5042905374 @default.
- W37070689 hasAuthorship W37070689A5066204364 @default.
- W37070689 hasAuthorship W37070689A5075249830 @default.
- W37070689 hasAuthorship W37070689A5086368387 @default.
- W37070689 hasConcept C104317684 @default.
- W37070689 hasConcept C153911025 @default.
- W37070689 hasConcept C167625842 @default.
- W37070689 hasConcept C170493617 @default.
- W37070689 hasConcept C185592680 @default.
- W37070689 hasConcept C187882448 @default.
- W37070689 hasConcept C2775960820 @default.
- W37070689 hasConcept C2780378035 @default.
- W37070689 hasConcept C2780689927 @default.
- W37070689 hasConcept C515207424 @default.
- W37070689 hasConcept C55493867 @default.
- W37070689 hasConcept C80862487 @default.
- W37070689 hasConcept C86803240 @default.
- W37070689 hasConceptScore W37070689C104317684 @default.
- W37070689 hasConceptScore W37070689C153911025 @default.
- W37070689 hasConceptScore W37070689C167625842 @default.
- W37070689 hasConceptScore W37070689C170493617 @default.
- W37070689 hasConceptScore W37070689C185592680 @default.
- W37070689 hasConceptScore W37070689C187882448 @default.
- W37070689 hasConceptScore W37070689C2775960820 @default.
- W37070689 hasConceptScore W37070689C2780378035 @default.
- W37070689 hasConceptScore W37070689C2780689927 @default.
- W37070689 hasConceptScore W37070689C515207424 @default.
- W37070689 hasConceptScore W37070689C55493867 @default.
- W37070689 hasConceptScore W37070689C80862487 @default.
- W37070689 hasConceptScore W37070689C86803240 @default.
- W37070689 hasLocation W370706891 @default.
- W37070689 hasLocation W370706892 @default.
- W37070689 hasOpenAccess W37070689 @default.
- W37070689 hasPrimaryLocation W370706891 @default.
- W37070689 hasRelatedWork W1994711691 @default.
- W37070689 hasRelatedWork W2011881892 @default.
- W37070689 hasRelatedWork W2162625483 @default.
- W37070689 hasRelatedWork W2341920515 @default.
- W37070689 hasRelatedWork W2346048935 @default.
- W37070689 hasRelatedWork W2359219901 @default.
- W37070689 hasRelatedWork W2748952813 @default.
- W37070689 hasRelatedWork W2899084033 @default.
- W37070689 hasRelatedWork W2950036879 @default.
- W37070689 hasRelatedWork W3136415254 @default.
- W37070689 isParatext "false" @default.
- W37070689 isRetracted "false" @default.
- W37070689 magId "37070689" @default.
- W37070689 workType "book-chapter" @default.