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- W37089573 abstract "This research develops a bio-nanotechnology for mechanically handling individual DNA fibers. The current study particularly focuses on surgery of a chromosome, which is a long strand of DNA tightly wound on proteins. Since DNA wound on a chromosome is several centimeter long, it is too long to observe under a microscope. Therefore, it is necessary to develop a method for partial unwinding. This work uses laser-induced local heating. Focusing a laser beam onto an aimed location on a chromosome immersed in protease solution, induces temperature to rise and locally activates the enzymatic reaction. This work demonstrates stretching DNA fibers out of a chromosome using electro-osmotic flow. Results show a chromosome immobilized onto a glass surface with released DNA fibers as long as 150μm." @default.
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- W37089573 date "2009-01-01" @default.
- W37089573 modified "2023-09-26" @default.
- W37089573 title "Stretching DNA Fibers out of a Chromosome in Solution Using Electro-osmotic Flow" @default.
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