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• W37122285 endingPage "175" @default.
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• W37122285 abstract "To investigate the proteolytic contribution of tumor-associated macrophages (TAM) in tumor invasion, we analyzed whether TAM at the invasive front of small HCC in Abcb4(-/-)-mice show an enhanced expression of MMP-9.Liver cryosections of the hepatocellular carcinoma (HCC) invasive front from 12 mo old Abcb4(-/-)-mice were stained for collagen type I and MMP-9 using Alexa488 and Alexa568 labeled secondary antibodies. Afterwards, the Alexa568 dye was bleached and the macrophage marker F4/80 was visualized using Alexa568 labeled secondary antibodies. Finally, photographs of the invasive tumor front were digitally overlaid and analyzed.After complete bleaching of the primary dye, specific fluorescence staining of a third antigen, here F4/80, was successfully performed on the same histological section. With this method, we were able to identify conglomerates of matrix metalloproteinase (MMP-9) expressing macrophages within the tumor capsule of HCC.MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC. The described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry, facilitating visualization of at least three different antigens plus nuclei in one single histological section." @default.
• W37122285 created "2016-06-24" @default.
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• W37122285 date "2010-01-01" @default.
• W37122285 modified "2023-10-16" @default.
• W37122285 title "Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC" @default.
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• W37122285 doi "https://doi.org/10.4254/wjh.v2.i5.175" @default.
• W37122285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2999283" @default.
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