Matches in SemOpenAlex for { <https://semopenalex.org/work/W37152122> ?p ?o ?g. }
- W37152122 abstract "Publisher Summary This chapter reveals the relationship between deficiency of the C1 or C2 chromosomes with systemic lupus erythematosus. It begins with some background data on the structure and function of the class III complement genes and their protein products. Following this, it reviews the older data relative to the complement's long-appreciated role in immune complex (IC) handling. The new tools in this field, namely knockout mice, have been helpful in establishing an important role for the complement in innate and adaptive immunity as well as in preventing autoimmunity. A problem faced by a C-deficient host revolves around the clearance of foreign antigens and damaged self. The lack of C3b deposition on an IC leads to impaired antigen localization such as to follicular areas of the spleen. This appears to be a critical factor in the poor antibody response of such individuals. In a C-deficient host, there are several avenues to a vasculitic state. Prolonged antigenemia results in conditions such as in hepatitis B and C infections. In a C-deficient host, even normal amounts of IC, in association with infections or associated with physiologic tissue turnover and cell death, have a greater likelihood of being inappropriately processed. The prevention of IC precipitation in vascular structures, their adherence to erythrocytes or leukocytes, and their transport to and deposition in the liver and spleen are all likely to be impaired. Finally, the chapter discusses some recent results on the complement's key role in instructing adaptive immunity and in processing cellular debris." @default.
- W37152122 created "2016-06-24" @default.
- W37152122 creator A5008114290 @default.
- W37152122 creator A5060114670 @default.
- W37152122 date "2011-01-01" @default.
- W37152122 modified "2023-09-24" @default.
- W37152122 title "Genetic Susceptibility and Class III Complement Genes" @default.
- W37152122 cites W123679325 @default.
- W37152122 cites W128956352 @default.
- W37152122 cites W1481544517 @default.
- W37152122 cites W1486381049 @default.
- W37152122 cites W1502767033 @default.
- W37152122 cites W1507389886 @default.
- W37152122 cites W1508515609 @default.
- W37152122 cites W1513433245 @default.
- W37152122 cites W1543366016 @default.
- W37152122 cites W1543650651 @default.
- W37152122 cites W1554698729 @default.
- W37152122 cites W1563166241 @default.
- W37152122 cites W1566700659 @default.
- W37152122 cites W1574593386 @default.
- W37152122 cites W1575910327 @default.
- W37152122 cites W1580110709 @default.
- W37152122 cites W1582151620 @default.
- W37152122 cites W1587121765 @default.
- W37152122 cites W1587809300 @default.
- W37152122 cites W1600693909 @default.
- W37152122 cites W1604827020 @default.
- W37152122 cites W1606230757 @default.
- W37152122 cites W1608132596 @default.
- W37152122 cites W1609249008 @default.
- W37152122 cites W1618000363 @default.
- W37152122 cites W1647396871 @default.
- W37152122 cites W1651166025 @default.
- W37152122 cites W1654203370 @default.
- W37152122 cites W183326179 @default.
- W37152122 cites W1849254712 @default.
- W37152122 cites W1865840289 @default.
- W37152122 cites W1896514445 @default.
- W37152122 cites W1911106125 @default.
- W37152122 cites W1917304705 @default.
- W37152122 cites W1945739033 @default.
- W37152122 cites W1956186371 @default.
- W37152122 cites W1963662381 @default.
- W37152122 cites W1963680434 @default.
- W37152122 cites W1966845759 @default.
- W37152122 cites W1967238055 @default.
- W37152122 cites W1968489524 @default.
- W37152122 cites W1968510808 @default.
- W37152122 cites W1970946495 @default.
- W37152122 cites W1972023523 @default.
- W37152122 cites W1974178716 @default.
- W37152122 cites W1974633545 @default.
- W37152122 cites W1983094833 @default.
- W37152122 cites W1983385896 @default.
- W37152122 cites W1983644831 @default.
- W37152122 cites W1984505687 @default.
- W37152122 cites W1984587156 @default.
- W37152122 cites W1985401925 @default.
- W37152122 cites W1985437611 @default.
- W37152122 cites W1985773012 @default.
- W37152122 cites W1987207806 @default.
- W37152122 cites W1988087947 @default.
- W37152122 cites W1988328263 @default.
- W37152122 cites W1995810477 @default.
- W37152122 cites W1996480927 @default.
- W37152122 cites W1997761753 @default.
- W37152122 cites W1998056669 @default.
- W37152122 cites W1998717993 @default.
- W37152122 cites W1998780818 @default.
- W37152122 cites W2001724897 @default.
- W37152122 cites W2003577132 @default.
- W37152122 cites W2004844848 @default.
- W37152122 cites W2004871773 @default.
- W37152122 cites W2005961909 @default.
- W37152122 cites W2006176779 @default.
- W37152122 cites W2006182096 @default.
- W37152122 cites W2008945896 @default.
- W37152122 cites W2010160850 @default.
- W37152122 cites W2010233848 @default.
- W37152122 cites W2011001330 @default.
- W37152122 cites W2012751955 @default.
- W37152122 cites W2013405032 @default.
- W37152122 cites W2015265853 @default.
- W37152122 cites W201552997 @default.
- W37152122 cites W2015597797 @default.
- W37152122 cites W2016102616 @default.
- W37152122 cites W2016322525 @default.
- W37152122 cites W2020115285 @default.
- W37152122 cites W2020707013 @default.
- W37152122 cites W2023202999 @default.
- W37152122 cites W2023843441 @default.
- W37152122 cites W2024626915 @default.
- W37152122 cites W2025510766 @default.
- W37152122 cites W2025946466 @default.
- W37152122 cites W2025998055 @default.
- W37152122 cites W2026206453 @default.
- W37152122 cites W2027323192 @default.
- W37152122 cites W2029792780 @default.
- W37152122 cites W2031185382 @default.