Matches in SemOpenAlex for { <https://semopenalex.org/work/W3721018> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3721018 endingPage "63" @default.
- W3721018 startingPage "852" @default.
- W3721018 abstract "The three best-described genetic polymorphisms of drug metabolism--the debrisoquin/sparteine type of oxidative polymorphism (hereafter referred to as the debrisoquin polymorphism), the polymorphism of N-acetylation, and the mephenytoin type of oxidative polymorphism--are reviewed. For all three polymorphisms, the poor-metabolizer phenotype is inherited as an autosomal recessive trait. The debrisoquin and mephenytoin oxidative polymorphisms involve defects in two separate cytochrome P450 enzymes. The prevalence of the poor-metabolizer phenotype for debrisoquin ranges between 2% and 10% for groups of various ethnic origins. The poor-metabolizer phenotype for mephenytoin comprises about 5% of the Caucasian population and about 20% of the Japanese population. N-acetyltransferase is a cytosolic enzyme whose clinical polymorphism was discovered using isoniazid as the substrate probe. The prevalence of the slow-acetylator phenotype among American and European Caucasian and American black groups is about 50%; among the Japanese it is about 10%. More than 20 agents are substrates for debrisoquin hydroxylase, about 15 for N-acetyltransferase, and 3-5 for mephenytoin. In poor metabolizers, debrisoquin can cause hypotension, and sparteine can cause blurred vision, headache, and dizziness. Clinical consequences of the slow-acetylator phenotype include increased susceptibility to systemic lupus erythematosus induced by procainamide and hydralazine, peripheral neuropathy induced by isoniazid, hydralazine, and dapsone, and sulfasalazine-induced dose-related leukopenia, nausea, vomiting, headache, and vertigo. After administration of mephenytoin, poor metabolizers have increased somnolence and intellectual impairment. Awareness of genetic polymorphisms of drug metabolism should improve understanding of interindividual variability in drug disposition and response." @default.
- W3721018 created "2016-06-24" @default.
- W3721018 creator A5060815495 @default.
- W3721018 date "1989-12-01" @default.
- W3721018 modified "2023-09-23" @default.
- W3721018 title "Polymorphic drug metabolism." @default.
- W3721018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2689060" @default.
- W3721018 hasPublicationYear "1989" @default.
- W3721018 type Work @default.
- W3721018 sameAs 3721018 @default.
- W3721018 citedByCount "22" @default.
- W3721018 countsByYear W37210182012 @default.
- W3721018 countsByYear W37210182014 @default.
- W3721018 countsByYear W37210182015 @default.
- W3721018 countsByYear W37210182016 @default.
- W3721018 countsByYear W37210182017 @default.
- W3721018 countsByYear W37210182020 @default.
- W3721018 crossrefType "journal-article" @default.
- W3721018 hasAuthorship W3721018A5060815495 @default.
- W3721018 hasConcept C104317684 @default.
- W3721018 hasConcept C126322002 @default.
- W3721018 hasConcept C135763542 @default.
- W3721018 hasConcept C140840227 @default.
- W3721018 hasConcept C2776838488 @default.
- W3721018 hasConcept C2777600422 @default.
- W3721018 hasConcept C2908647359 @default.
- W3721018 hasConcept C33664856 @default.
- W3721018 hasConcept C526171541 @default.
- W3721018 hasConcept C54355233 @default.
- W3721018 hasConcept C55775858 @default.
- W3721018 hasConcept C62231903 @default.
- W3721018 hasConcept C71924100 @default.
- W3721018 hasConcept C86803240 @default.
- W3721018 hasConcept C98274493 @default.
- W3721018 hasConcept C99454951 @default.
- W3721018 hasConceptScore W3721018C104317684 @default.
- W3721018 hasConceptScore W3721018C126322002 @default.
- W3721018 hasConceptScore W3721018C135763542 @default.
- W3721018 hasConceptScore W3721018C140840227 @default.
- W3721018 hasConceptScore W3721018C2776838488 @default.
- W3721018 hasConceptScore W3721018C2777600422 @default.
- W3721018 hasConceptScore W3721018C2908647359 @default.
- W3721018 hasConceptScore W3721018C33664856 @default.
- W3721018 hasConceptScore W3721018C526171541 @default.
- W3721018 hasConceptScore W3721018C54355233 @default.
- W3721018 hasConceptScore W3721018C55775858 @default.
- W3721018 hasConceptScore W3721018C62231903 @default.
- W3721018 hasConceptScore W3721018C71924100 @default.
- W3721018 hasConceptScore W3721018C86803240 @default.
- W3721018 hasConceptScore W3721018C98274493 @default.
- W3721018 hasConceptScore W3721018C99454951 @default.
- W3721018 hasIssue "12" @default.
- W3721018 hasLocation W37210181 @default.
- W3721018 hasOpenAccess W3721018 @default.
- W3721018 hasPrimaryLocation W37210181 @default.
- W3721018 hasRelatedWork W2007367734 @default.
- W3721018 hasRelatedWork W2043942904 @default.
- W3721018 hasRelatedWork W2049856039 @default.
- W3721018 hasRelatedWork W2064302284 @default.
- W3721018 hasRelatedWork W2076934626 @default.
- W3721018 hasRelatedWork W2077067141 @default.
- W3721018 hasRelatedWork W2158147410 @default.
- W3721018 hasRelatedWork W2398832535 @default.
- W3721018 hasRelatedWork W2411007236 @default.
- W3721018 hasRelatedWork W2899084033 @default.
- W3721018 hasVolume "8" @default.
- W3721018 isParatext "false" @default.
- W3721018 isRetracted "false" @default.
- W3721018 magId "3721018" @default.
- W3721018 workType "article" @default.