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- W372153909 abstract "SummaryA double blind randomised trial of topical therapy with 3% Acyclovir (Zovirax) eye ointment, or placebo ointment, each used 5 times daily following treatment of dendritic ulcers by minimum wiping debridement was carried out on 24 men. There were 7 recurrences of microscopic foci of epithelial herpetic disease in the 12 patients treated with placebo but none in the 12 treated with Acyclovir (ACV). A second double blind randomised trial was carried out treating dendritic ulcers with either 3% ACV or 1% IDU ointment. Each ointment was applied 5 times daily until the ulcer was healed, and thereafter for a further 3 days. All ulcers healed within 10 days. There was a trend in favour of ACV but from a logrank analysis of the cumulative frequency distribution curves of healing times. Both medications were equivalent.These results prove that 3% Acyclovir ointment is an active antiviral in herpetic epithelial ulcers and that it is at least as effective as 1% IDU ointment when used 5 times daily.Seven of 38 patients using one batch of acyclovir ointment developed minor punctate staining with Bengal rose on the lower third of the bulbar conjunctiva. In two it extended onto the cornea." @default.
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- W372153909 date "1981-01-01" @default.
- W372153909 modified "2023-09-23" @default.
- W372153909 title "Acyclovir (Zovirax) in the Management of Herpetic Keratitis" @default.
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- W372153909 doi "https://doi.org/10.1007/978-3-642-80499-1_47" @default.
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