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- W37219058 abstract "Reperfusion injury triggers acute and chronic damage to multiple organs. Taurine treatment appears to reduce these injuries. This study tests the hypothesis that perinatal taurine exposure reduces the severity of cardiac reperfusion injury in the adult male rats. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Male offspring were fed normal rat chow and water containing 5% glucose (CG, TSG, TDG) or water alone (CW, TSW, TDW) throughout the experiment. At 7–8 weeks of age, all rats were anesthetized and their trachea clamped until cardiac arrest occurred and mean arterial pressure fell below 60 mm Hg. The clamp was immediately released and cardiopulmonary resuscitation was performed with cardiac function returning within 4 min. Circulating markers of cardiac injury were measured 2 days later. Plasma aspartate aminotransferase increased in all glucose treated and TDW rats, but the increase was nearly 3X greater in TDG vs. any other group. Creatine kinase-MB increased in all treatment groups but was far greater in TD than other groups. Troponin-I and brain natriuretic peptide were greatly increased in TDG compared to all other groups. These data indicate that high dietary sugar together with early life taurine depletion exacerbates cardiac reperfusion damage in adult rats." @default.
- W37219058 created "2016-06-24" @default.
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- W37219058 date "2010-04-01" @default.
- W37219058 modified "2023-09-25" @default.
- W37219058 title "High dietary sugar exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats" @default.
- W37219058 doi "https://doi.org/10.1096/fasebj.24.1_supplement.601.4" @default.
- W37219058 hasPublicationYear "2010" @default.
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